Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture

被引：5

作者：

Hrelia, S

Pession, A

Buda, R

Lorenzini, A

Horrobin, DF

Biagi, PL

Bordoni, A

机构：

[1] Univ Bologna, Dept Biochem G Moruzzi, I-40126 Bologna, Italy

[2] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[3] Laxdale Ltd, Stirling, Scotland

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1999年 / 60卷 / 04期

关键词：

D O I：

10.1054/plef.1999.0030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.

引用

页码：235 / 241

页数：7

共 27 条

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