Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress

被引：14

作者：

Maity, Moulima ^{[1
,2
]}

Perveen, Hasina ^{[1
,2
]}

Dash, Moumita ^{[1
,2
]}

Jana, Suryashis ^{[1
,2
]}

Khatun, Shamima ^{[1
,2
]}

Dey, Arindam ^{[1
,2
]}

Mandal, Amit Kumar ^{[3
,4
]}

Chattopadhyay, Sandip ^{[1
,2
]}

机构：

[1] Vidyasagar Univ, Dept Biomed Lab Sci & Management, Midnapore 721102, W Bengal, India

[2] Vidyasagar Univ, Clin Nutr & Dietet Div, Midnapore 721102, W Bengal, India

[3] Vidyasagar Univ, Dept Microbiol, Midnapore 721102, W Bengal, India

[4] Raiganj Univ, Dept Sericulture, Chem Biol Lab, Uttar Dinajpur 733134, W Bengal, India

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2018年 / 182卷 / 01期

关键词：

Arsenic; Uterine oxidative stress; Arjunolic acid; Vitamin B-12; Folic acid; SAM; LACTATE-DEHYDROGENASE; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; PANCREATIC-CANCER; SODIUM ARSENITE; DRINKING-WATER; DNA-DAMAGE; TOXICITY; OVARIAN;

D O I：

10.1007/s12011-017-1077-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given sodium arsenite (10 mg/kg body weight) in combination with arjunolic acid (10 mg/kg body weight) orally for two estrous cycles. Electrozymographic analysis explored that arjunolic acid co-treatment counteracted As3+-induced ROS production in uterine tissue by stimulating the activities of endogenous enzymatic antioxidants. Arjunolic acid was able to enhance the protection against mutagenic uterine DNA breakage, necrosis, and ovarian-uterine tissue damages in arsenicated rats by improving the ovarian steroidogenesis. The mechanisms might be coupled with the augmentation of antioxidant defense system, partly through the elimination of arsenic with the involvement of S-adenosyl methionine pool where circulating levels of vitamin B-12, folic acid, and homocysteine play critical roles as evidenced from our present investigation.

引用

页码：78 / 90

页数：13