Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

被引：57

作者：

Baek, Gui-Hyun ^{[2
]}

Jang, Yong-Suk ^{[2
]}

Jeong, Seung-Il ^{[3
]}

Cha, Jaeho ^{[4
]}

Joo, Myungsoo ^{[1
]}

Shin, Sang-Woo ^{[1
]}

Ha, Ki-Tae ^{[1
]}

Jeong, Han-Sol ^{[1
]}

机构：

[1] Pusan Natl Univ, Sch Korean Med, Div Appl Med, Yangsan 626870, South Korea

[2] Chonbuk Natl Univ, Dept Mol Biol, Jeonju 561756, South Korea

[3] Jeonju Biomat Inst, Jeonju 561360, South Korea

[4] Pusan Natl Univ, Coll Nat Sci, Dept Microbiol, Pusan 609735, South Korea

来源：

INFLAMMATION | 2012年 / 35卷 / 04期

关键词：

Rehmannia glutinosa; advanced glycation end products; THP-1; NF-kappa B; pro-inflammation; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; DIABETIC-RATS; ENDPRODUCTS AGES; HUMAN MONOCYTES; OXIDANT STRESS; RENAL-FUNCTION; RECEPTOR; RAGE; NEPHROPATHY;

D O I：

10.1007/s10753-012-9433-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fresh rhizome of Rehmannia glutinosa Libosch. (Saeng-jihwang in Korean: SJH) has been prescribed for the treatment of diabetes-associated complications. The purpose of the present study is to investigate the underlying mechanisms of the efficacy of SJH in diabetes-related complications. Decoction was obtained after boiling SJH in water and subsequent lyophilization. The cellular toxicity of SJH was determined by MTT assay. The antioxidant activity of SJH was measured by DPPH and DCFH-DA assays. The effects of SJH on inflammatory responses elicited by AGEs were assessed by western blotting and semi-quantitative RT-PCR analyses. The water extract of SJH had a high free radical scavenging activity in vitro and decreased the level of intracellular ROS in THP-1 cells treated with AGEs. SJH suppressed the expression of pro-inflammatory genes, including TNF-alpha, MCP-1, IP-10, COX-2, and iNOS; the activation of NF-kappa B; and the expression of RAGE, a receptor for AGEs, where the expressions of which were induced by AGEs. These results suggest the possibility that SJH can be an alternative therapeutics for diabetes-associated diseases.

引用

页码：1232 / 1241

页数：10

共 55 条

[11] ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure [J].

Doggrell, SA .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (05) :981-983

[12] MECHANISTIC STUDIES OF ADVANCED GLYCOSYLATION END-PRODUCT INHIBITION BY AMINOGUANIDINE [J].

EDELSTEIN, D ;

BROWNLEE, M .

DIABETES, 1992, 41 (01) :26-29

[13] LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats [J].

Figarola, JL ;

Scott, S ;

Loera, S ;

Tessler, C ;

Chu, P ;

Weiss, L ;

Hardy, J ;

Rahbar, S .

DIABETOLOGIA, 2003, 46 (08) :1140-1152

[14] Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis [J].

Forbes, JM ;

Yee, LTL ;

Thallas, V ;

Lassila, M ;

Candido, R ;

Jandeleit-Dahm, KA ;

Thomas, MC ;

Burns, WC ;

Deemer, EK ;

Thorpe, SM ;

Cooper, ME ;

Allen, TJ .

DIABETES, 2004, 53 (07) :1813-1823

[15] Increased serum levels of the specific advanced glycation end product methylglyoxal-derived hydroimidazolone are associated with retinopathy in patients with type 2 diabetes mellitus [J].

Fosmark, DS ;

Torjesen, PA ;

Kilhovd, BK ;

Berg, TJ ;

Sandvik, L ;

Hanssen, KF ;

Agardh, CD ;

Agardh, E .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (02) :232-236

[16] Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice [J].

Harja, Evis ;

Bu, De-Xiu ;

Hudson, Barry I. ;

Chang, Jong Sun ;

Shen, Xiaoping ;

Hallam, Kellie ;

Kalea, Anastasia Z. ;

Lu, Yan ;

Rosario, Rosa H. ;

Oruganti, Sai ;

Nikolla, Zana ;

Belov, Dmitri ;

Lalla, Evanthia ;

Ramasamy, Ravichandran ;

Yan, Shi Fang ;

Schmidt, Ann Marie .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :183-194

[17] Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats [J].

Huang, Wei-Jan ;

Niu, Ho-Shan ;

Lin, Mei-Hsiang ;

Cheng, Juei-Tang ;

Hsu, Fen-Lin .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (06) :1170-1172

[18] Diabetes and advanced glycoxidation end products [J].

Huebschmann, Amy G. ;

Regensteiner, Judith G. ;

Vlassara, Helen ;

Reusch, Jane E. B. .

DIABETES CARE, 2006, 29 (06) :1420-1432

[19]

JIANG YL, 1992, J IMMUNOL, V148, P2423

[20] Rehmannia glutinose ameliorates renal function in the ischemia/reperfusion-induced acute renal failure rats [J].

Kang, DG ;

Sohn, EJ ;

Moon, MK ;

Lee, YM ;

Lee, HS .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (09) :1662-1667

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