Genetic counseling in melanoma

被引：24

作者：

Badenas, Celia ^{[1
,3
]}

Aguilera, Paula ^{[2
,3
,4
]}

Puig-Butille, Joan A. ^{[3
]}

Carrera, Cristina ^{[2
,3
,4
]}

Malvehy, Josep ^{[2
,3
,4
]}

Puig, Susana ^{[2
,3
,4
]}

机构：

[1] Hosp Clin Barcelona, Melanoma Unit, Biochem & Mol Genet Serv, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, Melanoma Unit, Dept Dermatol, E-08036 Barcelona, Spain

[3] CIBERER, Barcelona, Spain

[4] IDIBAPS, Barcelona, Spain

来源：

DERMATOLOGIC THERAPY | 2012年 / 25卷 / 05期

关键词：

gene; genetic counseling; melanoma; mutation; predisposition; MELANOCORTIN; 1; RECEPTOR; HIGH-RISK; CUTANEOUS MELANOMA; CDKN2A MUTATIONS; FOLLOW-UP; VARIANT; MC1R; INHIBITION; FAMILIES; CANCER;

D O I：

10.1111/j.1529-8019.2012.01499.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Genetic counseling may be offered to families with melanoma and to individuals with multiple melanomas to better understand the genetic susceptibility of the disease, the influence of environmental factors, the inheritance of the risk, and behavior that decreases the risk of dying from melanoma, including specific dermatological follow-up such as total body photography and digital dermoscopy. Genetic testing may be offered to those individuals with more than a 10% chance of being a carrier of a mutation. This risk varies according to the incidence of melanoma in the country and sun behavior. In countries with a low-medium incidence of melanoma, genetic testing should be offered to families with two cases of melanoma or an individual with two primary melanomas. In countries with a high incidence, families with three cases of melanoma, with two melanomas and one pancreatic adenocarcinoma, or patients with three primary melanomas, may benefit from genetic testing.

引用

页码：397 / 402

页数：6

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