Novel TEMPO-PEG-RGDs Conjugates Remediate Tissue Damage Induced by Acute Limb Ischemia/Reperfusion

被引：16

作者：

Bi, Wei ^{[3
]}

Li, Xiaoxu ^{[4
]}

Bi, Yue ^{[3
]}

Xue, Ping ^{[3
]}

Zhang, Yanrong ^{[3
]}

Gao, Xiang ^{[3
]}

Wang, Zhibo ^{[3
]}

Li, Meng ^{[3
]}

Itagaki, Yasuhiro ^{[2
]}

Bi, Lanrong ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

[3] HeBei Med Univ, Hosp 2, Dept Surg, Shijiazhuang 050000, Peoples R China

[4] Columbia Univ, Coll Phys & Surg, New York, NY 10027 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 09期

关键词：

DUAL-ACTING AGENTS; POLYETHYLENE-GLYCOL; ISCHEMIA-REPERFUSION; COLD ISCHEMIA; NITRIC-OXIDE; INJURY; DESIGN;

D O I：

10.1021/jm201381w

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have recently developed new Tempo-PEG-RGDs conjugates and have quantitatively examined their antithrombotic and antioxidant capabilities. These compounds were therapeutically beneficial when characterized in both in vitro platelet aggregation assays and a rat model of arterial thrombosis. Moreover, these compounds demonstrated significant protection from organ damage in a rat model of ischemia/reperfusion. Our data indicate that Tempo-PEG-RGDs represent a new class of adjuvants with therapeutic efficacy in acute and transient ischemic damage.

引用

页码：4501 / 4505

页数：5

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