The functional roles of S1P in immunity

被引：58
作者：
Hisano, Yu [1 ]
Nishi, Tsuyoshi [2 ,3 ]
Kawahara, Atsuo [1 ]
机构：
[1] Riken Quantitat Biol Ctr QBiC, Lab Cardiovasc Mol Dynam, Suita, Osaka 5650874, Japan
[2] Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Osaka 5600032, Japan
[3] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF BIOCHEMISTRY | 2012年 / 152卷 / 04期
基金：
日本学术振兴会;
关键词：
lipid mediator; sphingosine-1-phosphate; SPNS2; thymocyte egress; transporter; SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2; SPHINGOSINE; 1-PHOSPHATE; LYMPHOCYTE EGRESS; CELL-MIGRATION; RECEPTOR; FTY720; ENDOTHELIUM; METABOLISM; PLATELETS; RELEASE;
D O I：
10.1093/jb/mvs090
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The lipid mediator sphingosine-1-phosphate (S1P) is generated within cells from sphingosine by two sphingosine kinases (SPHK1 and SPHK2). Intracellularly synthesized S1P is released into the extracellular fluid by S1P transporters, including SPNS2. Released S1P binds specifically to the G protein-coupled S1P receptors (S1PR1/S1P(1)-S1PR5/S1P(5)), which activate a diverse range of downstream signalling pathways. Recent studies have proposed that one of the central physiological functions of intercellular S1P signalling is in lymphocyte trafficking in vivo because genetic disruption of SPHK1/2, SPNS2 or S1PR1/S1P(1) in mice induces a lymphopenia phenotype. In this review, we discuss the current understanding of intercellular S1P signalling in the context of immunity.
引用
收藏
页码：305 / 311
页数：7
相关论文
共 40 条
  • [1] Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration
    Allende, ML
    Dreier, JL
    Mandala, S
    Proia, RL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) : 15396 - 15401
  • [2] Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    Alvarez, Sergio E.
    Harikumar, Kuzhuvelil B.
    Hait, Nitai C.
    Allegood, Jeremy
    Strub, Graham M.
    Kim, Eugene Y.
    Maceyka, Michael
    Jiang, Hualiang
    Luo, Cheng
    Kordula, Tomasz
    Milstien, Sheldon
    Spiegel, Sarah
    [J]. NATURE, 2010, 465 (7301) : 1084 - U149
  • [3] The immunomodulator FTY720 is phosphorylated and released from platelets
    Anada, Yoshihiro
    Igarashi, Yasuyuki
    Kihara, Akio
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 568 (1-3) : 106 - 111
  • [4] Sphingosine 1-phosphate-related metabolism in the blood vessel
    Aoki, S
    Yatomi, Y
    Ohta, M
    Osada, M
    Kazama, F
    Satoh, K
    Nakahara, K
    Ozaki, Y
    [J]. JOURNAL OF BIOCHEMISTRY, 2005, 138 (01) : 47 - 55
  • [5] Lipid phosphate phosphatase 3 enables efficient thymic egress
    Breart, Beatrice
    Ramos-Perez, Willy D.
    Mendoza, Alejandra
    Salous, Abdelghaffar K.
    Gobert, Michael
    Huang, Yong
    Adams, Ralf H.
    Lafaille, Juan J.
    Escalante-Alcalde, Diana
    Morris, Andrew J.
    Schwab, Susan R.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (06) : 1267 - 1278
  • [6] Lipid phosphate phosphatases and signaling
    Brindley, David N.
    Pilquil, Carlos
    [J]. JOURNAL OF LIPID RESEARCH, 2009, 50 : S225 - S230
  • [7] Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
    Brinkmann, Volker
    [J]. PHARMACOLOGY & THERAPEUTICS, 2007, 115 (01) : 84 - 105
  • [8] Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
    Brinkmann, Volker
    Billich, Andreas
    Baumruker, Thomas
    Heining, Peter
    Schmouder, Robert
    Francis, Gordon
    Aradhye, Shreeram
    Burtin, Pascale
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (11) : 883 - 897
  • [9] Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christoffersen, Christina
    Obinata, Hideru
    Kumaraswamy, Sunil B.
    Galvani, Sylvain
    Ahnstrom, Josefin
    Sevvana, Madhumati
    Egerer-Sieber, Claudia
    Muller, Yves A.
    Hla, Timothy
    Nielsen, Lars B.
    Dahlback, Bjorn
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) : 9613 - 9618
  • [10] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
    Fukuhara, Shigetomo
    Simmons, Szandor
    Kawamura, Shunsuke
    Inoue, Asuka
    Orba, Yasuko
    Tokudome, Takeshi
    Sunden, Yuji
    Arai, Yuji
    Moriwaki, Kazumasa
    Ishida, Junji
    Uemura, Akiyoshi
    Kiyonari, Hiroshi
    Abe, Takaya
    Fukamizu, Akiyoshi
    Hirashima, Masanori
    Sawa, Hirofumi
    Aoki, Junken
    Ishii, Masaru
    Mochizuki, Naoki
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (04) : 1416 - 1426
1234