The functional roles of S1P in immunity

被引：58

作者：

Hisano, Yu ^{[1
]}

Nishi, Tsuyoshi ^{[2
,3
]}

Kawahara, Atsuo ^{[1
]}

机构：

[1] Riken Quantitat Biol Ctr QBiC, Lab Cardiovasc Mol Dynam, Suita, Osaka 5650874, Japan

[2] Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Osaka 5600032, Japan

[3] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2012年 / 152卷 / 04期

基金：

日本学术振兴会;

关键词：

lipid mediator; sphingosine-1-phosphate; SPNS2; thymocyte egress; transporter; SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2; SPHINGOSINE; 1-PHOSPHATE; LYMPHOCYTE EGRESS; CELL-MIGRATION; RECEPTOR; FTY720; ENDOTHELIUM; METABOLISM; PLATELETS; RELEASE;

D O I：

10.1093/jb/mvs090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid mediator sphingosine-1-phosphate (S1P) is generated within cells from sphingosine by two sphingosine kinases (SPHK1 and SPHK2). Intracellularly synthesized S1P is released into the extracellular fluid by S1P transporters, including SPNS2. Released S1P binds specifically to the G protein-coupled S1P receptors (S1PR1/S1P(1)-S1PR5/S1P(5)), which activate a diverse range of downstream signalling pathways. Recent studies have proposed that one of the central physiological functions of intercellular S1P signalling is in lymphocyte trafficking in vivo because genetic disruption of SPHK1/2, SPNS2 or S1PR1/S1P(1) in mice induces a lymphopenia phenotype. In this review, we discuss the current understanding of intercellular S1P signalling in the context of immunity.

引用

页码：305 / 311

页数：7

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