Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?

被引：19
作者：
Abdallah, Chadi G. [1 ,2 ]
Krystal, John H. [1 ,2 ]
机构：
[1] US Dept Vet Affairs, Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA
[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2020年 / 390卷
关键词：
Depression; Antidepressants; Ketamine; Rapamycin; Synaptic plasticity; Relapse prevention; POSTTRAUMATIC-STRESS-DISORDER; HIPPOCAMPAL VOLUME; NUCLEUS-ACCUMBENS; MOOD DISORDERS; EFFICACY; SCHIZOPHRENIA; ABNORMALITIES; DYSCONNECTIVITY; CONNECTIVITY; ANXIETY;
D O I：
10.1016/j.bbr.2020.112628
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Depression is a leading cause of disability, with often chronic course of illness and high treatment resistance in a large proportion of patients. In the current short perspective paper, we present evidence supporting the presence of synaptic-based chronic stress pathology (CSP) in depression and across a number of psychiatric disorders. We summarize the synaptic connectivity model of CSP, and briefly review related preclinical and clinical evidence, while providing appropriate references for more comprehensive reviews and alternative models. We then underscore some gaps in the literature and provide various tips for future directions.
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页数：5
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