Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis

被引：54
作者：
Zhang, Z.-C.
Li, S.-J.
Yang, Y.-Z.
Chen, R.-Z.
Ge, J.-B.
Chen, H.-Z.
机构：
[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Minist Publ Hlth,Key Lab Viral Heart Dis, Shanghai 200032, Peoples R China
[2] Zhejiang Hosp, Hangzhou 310013, Zhenjiang Provi, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2007年 / 9卷 / 02期
基金：
中国国家自然科学基金;
关键词：
astragaloside; apoptosis; coxsackievirus B (CVB); myocarditis; microarray;
D O I：
10.1080/10286020412331286506
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Astragaloside is the major component of Astragalus membranaceus, one of the Chinese medical herbs, and has several pharmacological actions on cardiovascular system, including positive inotropic, antiarrhythmia and anti-oxidant activities. We have investigated the effect of astragaloside on cardiomyocyte apoptosis and expression of apoptosis-associated genes in mice with coxsackievirus B-3 (CVB3)-induced myocarditis, the former of which has been detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay and the latter determined by using a focused microarray. Results showed that cardiomyocyte apoptosis and expression of various apoptosis associated genes are inhibited after treatment with astragaloside. The anti-apoptotic activity of astragaloside may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus.
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页码：145 / 151
页数：7
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