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Grafting of poly(ethylene glycol) to chitosan at C(6) position of glucosamine units via "click chemistry" reactions
被引:0
作者:
Gruskiene, Ruta
[1
]
Ciuta, Gediminas
[1
]
Makuska, Ricardas
[1
]
机构:
[1] Vilnius State Univ, Dept Polymer Chem, LT-03225 Vilnius, Lithuania
来源:
CHEMIJA
|
2009年
/
20卷
/
04期
关键词:
chitosan;
poly(ethylene glycol);
click chemistry;
graft copolymer;
azidated chitosan;
POLYSACCHARIDES;
CYCLOADDITION;
DERIVATIVES;
LIGATION;
AZIDES;
TOOL;
D O I:
暂无
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
N-Phthaloyl chitosan derivatives containing azide or propargyl moieties at C(6) positionof glucosamine units were synthesized for the first time. The products obtained are useful as precursors for modification of chitosan via "click chemistry" reactions. New chitosan-MPEG derivatives containing intermediate triazolyl moieties at C(6) position of glucosamine units were prepared by coupling via 1,3-dipolar cycloaddition between azide and propargyl groups of chitosan and poly(ethylene glycol) monomethyl ether (MPEG). Comb copolymers were characterized by FT-IR and H-1 NMR spectroscopy, intrinsic viscosity, elemental and functional group analysis. The degree of chitosan substitution in new copolymers depended on the ratio of azide and propargyl groups and was in the range 20 to 65%, proving an efficient control of the graft density. The intrinsic viscosity of the chitosan derivatives was low, evidencing a significant degradation of the chitosan backbone during modification.
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页码:241 / 249
页数:9
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