Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology

被引：82
作者：
Spada, Sheila [1 ]
Tocci, Annalisa [2 ]
Di Modugno, Francesca [2 ]
Nistico, Paola [2 ]
机构：
[1] Weill Cornell Med, Dept Radiat Oncol, New York, NY USA
[2] IRCCS Regina Elena Natl Canc Inst, Tumor Immunol & Immunotherapy Unit, Rome, Italy
来源：
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2021年 / 40卷 / 01期
关键词：
Fibronectin; Fibrillogenesis; Extracellular matrix; Actin cytoskeleton; Cancer-associated fibroblasts; Metastasis; Dormant cells; Metastatic niche; Extracellular vesicles; Cancer; LUNG-CANCER CELLS; METASTATIC NICHE FORMATION; HEPARIN-BINDING DOMAIN; ED-B FIBRONECTIN; EXTRACELLULAR-MATRIX; BREAST-CANCER; TGF-BETA; PLASMA FIBRONECTIN; EXTRA DOMAIN; INTEGRIN ALPHA-5-BETA-1;
D O I：
10.1186/s13046-021-01908-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Deciphering extracellular matrix (ECM) composition and architecture may represent a novel approach to identify diagnostic and therapeutic targets in cancer. Among the ECM components, fibronectin and its fibrillary assembly represent the scaffold to build up the entire ECM structure, deeply affecting its features. Herein we focus on this extraordinary protein starting from its complex structure and defining its role in cancer as prognostic and theranostic marker.
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页数：14
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