Surface-Treatment-Induced Three-Dimensional Capillary Morphogenesis in a Microfluidic Platform

被引：70
作者：
Chung, Seok [3 ]
Sudo, Ryo [4 ]
Zervantonakis, Ioannis K. [1 ,2 ]
Rimchala, Tharathorn [1 ,2 ]
Kamm, Roger D. [1 ,2 ]
机构：
[1] MIT, Dept Engn Mech, Cambridge, MA 02139 USA
[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
[3] Korea Univ, Sch Mech Engn, Seoul 136713, South Korea
[4] Keio Univ, Dept Syst Design Engn, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
来源：
ADVANCED MATERIALS | 2009年 / 21卷 / 47期
基金：
美国国家科学基金会;
关键词：
ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS IN-VITRO; CELL-MIGRATION; COLLAGEN MATRICES; CULTURE; 3D; HYDROGEL; DEVICE; EXPRESSION; ENVIRONMENTS;
D O I：
10.1002/adma.200901727
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Robust induction of realistic angiogenesis into a 3D matrix material under simultaneous imaging and a stably controlled concentration gradient of chemoattractants is presented. The formation of a 3D vascular network is demonstrated to be a direct consequence of surface treatment of the region of the device-containing matrix material.
引用
收藏
页码：4863 / +
页数：6
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