Acquired haemophilia complicating the remission of a patient with high grade non-Hodgkin's lymphoma treated by fludarabine

被引：22

作者：

Tiplady, CW ^{[1
]}

Hamilton, PJ

Galloway, MJ

机构：

[1] Royal Victoria Infirm, Dept Haematol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[2] Bishop Auckland Hosp, Dept Haematol, Bishop Auckland, Durham, England

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 2000年 / 22卷 / 03期

关键词：

Fludarabine; acquired haemophilia; factor VIII inhibitor; non-Hodgkin's lymphoma;

D O I：

10.1046/j.1365-2257.2000.00308.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the development of a high titre antibody to factor VIII in a patient with previous high grade B cell non-Hodgkin's lymphoma treated with fludarabine. Unlike previous reports of factor VIII inhibitors and lymphoproliferative disease this patient's lymphoma was in remission. We speculate that the occurrence of the inhibitor is another manifestation of the increasingly recognized autoimmune side-effects of fludarabine.

引用

页码：163 / 165

页数：3

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