Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response

被引：17

作者：

Dehennaut, Vanessa ^{[1
]}

Leprince, Dominique ^{[1
]}

机构：

[1] Univ Lille Nord France, Inst Biol Lille, CNRS, Inst Pasteur Lille,UMR 8161,IFR 142, F-59017 Lille, France

来源：

BULLETIN DU CANCER | 2009年 / 96卷 / 11期

关键词：

HIC1; p53; SIRT1; E2F1; DNA damage; TUMOR-SUPPRESSOR GENE; TRANSCRIPTIONAL REPRESSION; REGULATES SIRT1; P53; IDENTIFICATION; PROMOTER; EXPRESSION; MECHANISM; COMPLEX; BINDING;

D O I：

10.1684/bdc.2009.0959

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Kruppel-like C2H2 zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1. triangle

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页码：E66 / E72

页数：7

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