Clinical factors predictive of bone marrow involvement in Hodgkin's disease

被引:13
作者
Spector, N
Nucci, M
DeMorais, JCO
Maiolino, A
Portugal, RD
Costa, MA
Pulcheri, W
机构
[1] UNIV FED RIO DE JANEIRO,UNIV HOSP,SERV HEMATOL,RIO JANEIRO,BRAZIL
[2] UNIV FED RIO DE JANEIRO,UNIV HOSP,PATHOL SERV,RIO JANEIRO,BRAZIL
[3] NATL CANC INST,ONCOL SERV,RIO JANEIRO,BRAZIL
关键词
Hodgkin's disease; bone marrow pathology; bone marrow examination; staging;
D O I
10.3109/10428199709109172
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The role of bone marrow biopsy in the staging of Hodgkin's disease is undergoing reevaluation. We have studied the relationship of clinical factors to the presence of bone marrow involvement in 130 previously untreated patients with Hodgkin's disease. The presence of fever, spleen enlargement, anemia, leukopenia, poor performance status and poor histologic subgroups were positively correlated with the presence of bone marrow involvement in the univariate analysis. In the multivariate analysis, only fever, spleen involvement, leukopenia and poor histologic subgroups were significant. The predictive value of the absence of fever in regard to the absence of bone marrow involvement was 98%. The likelihood of bone marrow involvement in the absence of all four significant factors was only 0.05%. Patients without these clinical factors should probably not be submitted to a bone marrow biopsy as part of the staging procedures performed in Hodgkin's disease.
引用
收藏
页码:171 / 176
页数:6
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