Diethyl Phosphite Promoted Electrochemical Oxidation of Tetrahydroisoquinolines to 3,4-Dihydroisoquinolin-1(2H)-ones

被引：12
|
作者：
Xie, Wenxia [1 ]
Gong, Bowen [1 ]
Ning, Shulin [1 ]
Liu, Nian [1 ]
Zhang, Zhuoqi [1 ]
Che, Xin [1 ]
Zheng, Lianyou [1 ]
Xiang, Jinbao [1 ]
机构：
[1] Jilin Univ, Ctr Combinatorial Chem & Drug Discovery, Sch Pharmaceut Sci, 1266 Fujin Rd, Changchun 130021, Jilin, Peoples R China
来源：
SYNLETT | 2019年 / 30卷 / 18期
关键词：
electrochemistry; oxidation; diethyl phosphite; tetrahydroisoquinoline; C=O bond formation; AMINES; DIHYDROISOQUINOLONES;
D O I：
10.1055/s-0039-1690704
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A diethyl phosphite mediated electrochemical oxidation strategy for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones from tetrahydroisoquinolines under mild conditions has been developed. This protocol provides an environmentally friendly and simple way for the construction of C=O bonds in an undivided cell unit.
引用
收藏
页码：2077 / 2080
页数：4
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