Diethyl Phosphite Promoted Electrochemical Oxidation of Tetrahydroisoquinolines to 3,4-Dihydroisoquinolin-1(2H)-ones

被引：12

作者：

Xie, Wenxia ^{[1
]}

Gong, Bowen ^{[1
]}

Ning, Shulin ^{[1
]}

Liu, Nian ^{[1
]}

Zhang, Zhuoqi ^{[1
]}

Che, Xin ^{[1
]}

Zheng, Lianyou ^{[1
]}

Xiang, Jinbao ^{[1
]}

机构：

[1] Jilin Univ, Ctr Combinatorial Chem & Drug Discovery, Sch Pharmaceut Sci, 1266 Fujin Rd, Changchun 130021, Jilin, Peoples R China

来源：

SYNLETT | 2019年 / 30卷 / 18期

关键词：

electrochemistry; oxidation; diethyl phosphite; tetrahydroisoquinoline; C=O bond formation; AMINES; DIHYDROISOQUINOLONES;

D O I：

10.1055/s-0039-1690704

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diethyl phosphite mediated electrochemical oxidation strategy for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones from tetrahydroisoquinolines under mild conditions has been developed. This protocol provides an environmentally friendly and simple way for the construction of C=O bonds in an undivided cell unit.

引用

页码：2077 / 2080

页数：4

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