Mast cells in airway diseases and interstitial lung disease

被引：45

作者：

Cruse, Glenn ^{[1
]}

Bradding, Peter ^{[2
]}

机构：

[1] NIAID, Lab Allerg Dis, NIH, Bldg 10,Rm 11C213,10 Ctr Dr MSC 1881, Bethesda, MD 20892 USA

[2] Univ Leicester, Glenfield Hosp, Dept Infect Immun & Inflammat, Inst Lung Hlth, Leicester LE3 9QP, Leics, England

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 778卷

基金：

美国国家卫生研究院;

关键词：

Mast cell; Asthma; Airway diseases; Interstitial lung disease; FC-EPSILON-RI; TUMOR-NECROSIS-FACTOR; BRONCHOALVEOLAR LAVAGE FLUID; FIBROBLAST-GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; OBSTRUCTIVE PULMONARY-DISEASE; C-KIT RECEPTOR; BRONCHIAL EPITHELIAL-CELLS; LOCAL ALLERGEN CHALLENGE; HUMAN-ENDOTHELIAL-CELLS;

D O I：

10.1016/j.ejphar.2015.04.046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mast cells are major effector cells of inflammation and there is strong evidence that mast cells play a significant role in asthma pathophysiology. There is also a growing body of evidence that mast cells contribute to other inflammatory and fibrotic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. This review discusses the role that mast cells play in airway diseases and highlights how mast cell microlocalisation within specific lung compartments and their cellular interactions are likely to be critical for their effector function in disease. Published by Elsevier B.V.

引用

页码：125 / 138

页数：14

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