First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127-T regulatory cells

被引：568

作者：

Trzonkowski, Piotr ^{[1
]}

Bieniaszewska, Maria ^{[2
]}

Juscinska, Jolanta ^{[3
]}

Dobyszuk, Anita ^{[1
]}

Krzystyniak, Adam ^{[1
]}

Marek, Natalia ^{[1
]}

Mysliwska, Jolanta ^{[4
]}

Hellmann, Andrzej ^{[2
]}

机构：

[1] Med Univ Gdansk, Dept Clin Immunol & Transplantol, PL-80211 Gdansk, Poland

[2] Med Univ Gdansk, Dept Hematol & Transplantol, PL-80211 Gdansk, Poland

[3] Blood Bank Pomerania Reg, Gdansk Unit, Gdansk, Poland

[4] Med Univ Gdansk, Dept Immunol, PL-80211 Gdansk, Poland

来源：

CLINICAL IMMUNOLOGY | 2009年 / 133卷 / 01期

关键词：

CD4+CD25+T regulatory cells; Adoptive transfer; Ex vivo expansion; Graft versus host disease; Immunotherapy; Human; ACTIVATED T-CELLS; ACUTE GVHD; EXPANSION; EXPRESSION; FOXP3; TOLERANCE; TRIALS;

D O I：

10.1016/j.clim.2009.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, we describe a procedure and first-in-man clinical effects of adoptive transfer of ex vivo expanded CD4+CD25+CD127-T regulatory cells (Tregs) in the treatment of graft versus host disease (GvHD). The cells were sorted from buffy coats taken from two family donors, expanded ex vivo and transferred to respective recipients who suffered from either acute or chronic GvHD. The therapy allowed for significant alleviation of the symptoms and reduction of pharmacologic immunosuppression in the case of chronic GvHD, while in the case of grade IV acute GvHD it only transiently improved the condition, for the longest time within all immunosuppressants used nonetheless. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：22 / 26

页数：5

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