Amino acids with fluorinated olefinic motifs - synthetic approaches

被引:0
作者
Salamon-Krokosz, Katarzyna [1 ]
Koroniak-Szejn, Katarzyna [1 ]
Koroniak, Henryk [1 ]
机构
[1] Adam Mickiewicz Univ, Fac Chem, Ul Uniwersytetu Poznanskiego 8, PL-60614 Poznan, Poland
关键词
Monofluorovinyl moiety; difluorovinyl moiety; trifluorovinyl moiety; amino acids; peptidomimetics; biological activity; ALPHA-TRIFLUOROMETHYL; AMINOTRANSFERASE; INHIBITORS; DESIGN; ISOSTERES; BEARING;
D O I
10.24820/ark.5550190.p011.366
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Peptidomimetics are molecules related to natural peptides that have an artificial unit incorporated in their structure. Such structural modifications, mimicking properties of natural amino acids, can be responsible for differently pronounced activity. Among others, amino acid derivatives with fluorinated olefinic motifies can act as building blocks in the synthesis of complex molecules with potential biological activity. Therefore, the synthetic approaches to the fluorinated olefinic moiety amino acids are of interest to organic chemists. There are different synthetic methods yielding fluorinated olefins having significant value in the synthesis of amino acid derivatives. This mini review describes the latest achievements in the synthesis of amino acids bearing mono-, di- or trifluorovinyl moiety.
引用
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页码:99 / 117
页数:19
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