Human Endothelial Cell Models in Biomaterial Research

被引：98

作者：

Hauser, Sandra ^{[1
]}

Jung, Friedrich ^{[3
,4
,5
]}

Pietzscht, Jens ^{[1
,2
]}

机构：

[1] Helmholtz Zentrum Dresden Rossendorf, Inst Radiopharmaceut Canc Res, Dept Radiopharmaceut & Chem Biol, Dresden, Germany

[2] Tech Univ Dresden, Dept Chem & Food Chem, Dresden, Germany

[3] Helmholtz Zentrum Geesthacht, Inst Biomat Sci, Teltow, Germany

[4] Helmholtz Zentrum Geesthacht, Berlin Brandenburg Ctr Regenerat Therapies, Teltow, Germany

[5] Helmholtz Virtual Inst Multifunct Biomat Med, Teltow, Germany

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 03期

关键词：

IN-VITRO; SMOOTH-MUSCLE; PROGENITOR CELLS; STAINLESS-STEEL; VASCULAR GRAFT; ANGIOGENESIS; SCAFFOLDS; COLLAGEN; SURFACE; VIVO;

D O I：

10.1016/j.tibtech.2016.09.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Endothelial cell (EC) models have evolved as important tools in biomaterial research due to ubiquitously occurring interactions between implanted materials and the endothelium. However, screening the available literature has revealed a gap between material scientists and physiologists in terms of their understanding of these biomaterial-endothelium interactions and their relative importance. Consequently, EC models are often applied in nonphysiological experimental setups, or too extensive conclusions are drawn from their results. The question arises whether this might be one reason why, among the many potential biomaterials, only a few have found their way into the clinic. In this review, we provide an overview of established EC models and possible selection criteria to enable researchers to determine the most reliable and relevant EC model to use.

引用

页码：265 / 277

页数：13

共 105 条

[21] Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture [J].