Deletion of a Histone Acetyltransferase Leads to the Pleiotropic Activation of Natural Products in Metarhizium robertsii

被引：62
作者：
Fan, Aili [1 ,3 ]
Mi, Wubin [2 ]
Liu, Zhiguo [1 ]
Zeng, Guohong [2 ]
Zhang, Peng [1 ]
Hu, Youcai [4 ,5 ]
Fang, Weiguo [2 ]
Yin, Wen-Bing [1 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
[2] Zhejiang Univ, Inst Microbiol, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China
[3] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
[4] Chinese Acad Med Sci, State Key Lab Bioact Substance & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China
[5] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ENDOPHYTIC FUNGUS; ANISOPLIAE; METABOLITES; GENE; BIOSYNTHESIS; STRAIN;
D O I：
10.1021/acs.orglett.7b00476
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Histone deacetylation normally decreases the gene expression in organisms. By genome-wide deletions of epigenetic regulators in entomopathogenic fungus Metarhizium robertsii unexpected activations of orphan secondary metabolite genes have been found upon the disruption of a histone acetyltransferase (HAT) gene Hat1. This led to the characterization of 11 new natural products, including eight isocoumarin derivatives meromusides A-H and two nonribosomal peptides meromutides A and B. Therefore, disruption of HAT represents a new approach to mine chemical diversity from fungi.
引用
收藏
页码：1686 / 1689
页数：4
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