Effect of poly(dimethylsiloxane)-block-poly(oligo (ethylene glycol) methacrylate) amphiphilic block copolymers on dermal fibroblast viability and proliferation

被引：2
|
作者：
Ebtedaei, Milad [1 ]
Jalili, Kiyumars [1 ,2 ]
Alizadeh, Najibeh [1 ]
Ghaleh, Hakimeh [1 ]
Abbasi, Farhang [1 ,2 ]
机构：
[1] Sahand Univ Technol, Inst Polymer Mat, Tabriz 5331817634, Iran
[2] Sahand Univ Technol, Fac Polymer Engn, Tabriz 5331817634, Iran
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2019年 / 30卷 / 15期
关键词：
Amphiphilic copolymer; poly(dimethylsiloxane); poly(oligo (ethylene glycol) methacrylate); hypertrophic wounds; dermal fibroblast apoptosis; SILOXANE OLIGOMERS; CELL VIABILITY; SILICONE; PREVENTION; RELEASE; PDMS;
D O I：
10.1080/09205063.2019.1642555
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this work, well-defined poly(dimethylsiloxane)-b-poly(oligo (ethylene glycol) methacrylate) (PDMS-b-POEGMA) amphiphilic block copolymers were synthesized and their effect on human dermal fibroblast were investigated. Anionic ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) were used to synthesis the block copolymers. The molecular weight of synthesized copolymers ranged from 1000 to 2300 Da by changing the number of both PDMS and POEGMA units. It was found that the copolymer having low molecular weight decreased the fibroblast viability and proliferation by inducing apoptosis. It was proved by flow cytometry and TUNEL assay that human dermal fibroblast experienced apoptosis after exposure to synthesized amphiphilic copolymers. The results of this work suggest the use of PDMS-b-POEGMA amphiphilic copolymers with low molecular weight for hypertrophic scars remediation.
引用
收藏
页码：1433 / 1453
页数：21
相关论文
共 50 条
  • [21] Preparation of poly(trimethylene carbonate)-block-poly(ethylene glycol)-block-poly(trimethylene carbonate) triblock copolymers under microwave irradiation
    Liao, Liqiong
    Zhang, Chao
    Gong, Shaoqin
    REACTIVE & FUNCTIONAL POLYMERS, 2008, 68 (03): : 751 - 758
  • [22] Nano-capsules of amphiphilic poly(ethylene glycol)-block-poly(bisphenol A carbonate) copolymers via thermodynamic entrapment
    Sutti, A.
    Chaffraix, T.
    Voda, A. S.
    Taylor, A.
    Magniez, K.
    RSC ADVANCES, 2016, 6 (08) : 6065 - 6071
  • [23] Synthesis of three types of amphiphilic poly(ethylene glycol)-block-poly (sebacic anhydride) copolymers and studies of their micellar solutions
    Zhang, Na
    Guo, Sheng Rong
    Li, Hui Qin
    Liu, Li
    Li, Zong Hai
    Gu, Jian Ren
    MACROMOLECULAR CHEMISTRY AND PHYSICS, 2006, 207 (15) : 1359 - 1367
  • [24] Novel synthesis of biodegradable star poly(ethylene glycol)-block-poly(lactide) copolymers
    Lemmouchi, Yahia
    Perry, Michael C.
    Amass, Allan J.
    Chakraborty, Khirud
    Schacht, Etienne
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2007, 45 (17) : 3966 - 3974
  • [25] Water-soluble complexes formed by poly(2-vinylpyridinium)-block-poly(ethylene oxide) and poly(sodium methacrylate)-block-poly(ethylene oxide) copolymers
    Gohy, JF
    Varshney, SK
    Jérôme, R
    MACROMOLECULES, 2001, 34 (10) : 3361 - 3366
  • [26] SURFACE-ACTIVITY OF POLY(ETHYLENE OXIDE)-BLOCK-POLY(PROPYLENE OXIDE)-BLOCK-POLY(ETHYLENE OXIDE) COPOLYMERS
    ALEXANDRIDIS, P
    ATHANASSIOU, V
    FUKUDA, S
    HATTON, TA
    LANGMUIR, 1994, 10 (08) : 2604 - 2612
  • [27] Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block-poly(ε-caprolactone) amphiphilic block copolymers
    Yan, Jinliang
    Ye, Zhaoyang
    Luo, Houyong
    Chen, Min
    Zhou, Yan
    Tan, Wensong
    Xiao, Yan
    Zhang, Yan
    Lang, Meidong
    POLYMER CHEMISTRY, 2011, 2 (06) : 1331 - 1340
  • [28] Preparation of jellyfish-shaped amphiphilic block-graft copolymers consisting of a poly(ε-caprolactone)-block-poly(pentafluorostyrene) ring and poly(ethylene glycol) lateral brushes
    Cai, Tao
    Yang, Wen Jing
    Neoh, Koon-Gee
    Kang, En-Tang
    POLYMER CHEMISTRY, 2012, 3 (04) : 1061 - 1068
  • [29] Tuning properties of poly(ethylene glycol)-block-poly(simvastatin) copolymers synthesized via triazabicyclodecene
    Asafo-Adjei, Theodora A.
    Dziubla, Thomas D.
    Puleo, David A.
    REACTIVE & FUNCTIONAL POLYMERS, 2017, 119 : 37 - 46
  • [30] Synthesis of Poly(vinyl acetate)-block-poly(dimethylsiloxane)-block-poly(vinyl acetate) Copolymers by Iodine Transfer Photopolymerization in Miniemulsion
    Tonnar, Jeff
    Pouget, Emmanuel
    Lacroix-Desmazes, Patrick
    Boutevin, Bernard
    MACROMOLECULAR SYMPOSIA, 2009, 281 : 20 - 30
12345