No Difference in Mood and Quality of Life in DHEA-S Deficient Adults with Addison's Disease vs. Type 2 Diabetes Patients with Normal DHEA-S Levels: Implications for Management of These Conditions

被引：4

作者：

Heald, Adrian H. ^{[1
]}

Walther, Andreas ^{[2
]}

Davis, Julian R. E. ^{[3
]}

Moreno, Gabriela Y. C. ^{[4
]}

Kane, John ^{[5
]}

Livingston, Mark ^{[6
]}

Fowler, Helen L. ^{[7
]}

机构：

[1] Univ Manchester, Salford Royal NHS Fdn Trust, Dept Endocrinol, Salford, Lancs, England

[2] Tech Univ Dresden, Dept Psychol, Dresden, Germany

[3] Manchester Royal Infirm, Dept Endocrinol, Manchester, Lancs, England

[4] Inst Politecn Nacl, Mexico City, DF, Mexico

[5] Salford Royal NHS Fdn Trust, Clin Biochem, Salford, Lancs, England

[6] Walsall Manor Hosp, Dept Blood Sci, Walsall, W Midlands, England

[7] Salford Royal NHS Fdn Trust, Behav Med, Salford, Lancs, England

来源：

FRONTIERS IN PSYCHOLOGY | 2017年 / 8卷

关键词：

DHEA deficiency; Addison's disease; mood; depression; quality of life; diabetes type 2; GENERAL HEALTH QUESTIONNAIRE; DEHYDROEPIANDROSTERONE REPLACEMENT; ADRENAL INSUFFICIENCY; SCALED VERSION; DEPRESSION; TRIAL; WOMEN;

D O I：

10.3389/fpsyg.2017.00764

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Patients with Addison's disease have relatively high rates of depression and anxiety symptoms compared with population-based reference samples. Addison's disease results in deficiency of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S). There is considerable debate about the specific effects of DHEA deficiency on energy level and mood. We measured emotional well-being in 16 patients with Addison's disease and a group of 16 hospital attendees with type 2 diabetes. Participants completed the General Health Questionnaire-28 (GHQ-28), the Hospital Anxiety and Depression Scale (HADS), the World Health Organization's quality of life assessment (WHOQOL-BREF) and the Holmes-Rahe life event scale. DHEA-S was low in Addison's patients (Addison's men: 0.5 +/- 0.1 mu mol/l [ normal range: 2.1-10.8] compared with diabetes men: 3.2 +/- 1.2 mu mol/l; Addison's women: 0.4 +/- 0.01 mu mol/l [ normal range: 1.0-11.5] compared with diabetes women: 2.2 +/- 0.71 mu mol/l). Testosterone levels were similar in both groups studied. There were no differences in emotional well-being and quality of life (QOL) between patients with Addison's disease and Type 2 Diabetes Mellitus as measured by GHQ-28 (Addison's: 22.4 +/- 2.6, Diabetes: 19.6 +/- 2.7), HADS Depression (Addison's: 5.4 +/- 0.9, Diabetes: 4.5 +/- 1.4), HADS Anxiety and WHOQOL-BREF. There were no gender differences in affective symptomatology within the Addison's group. Life event scores were above average in both groups (Addison's: 195 +/- 39.6, Diabetes: 131 +/- 43.8), but not significant for difference between groups as was GHQ-28 total score. Both groups scored highly on the GHQ-28 and the life event scale, indicative of poorer health perceptions than the general population. This could be due to the chronicity of both disorders. We have not identified any specific effects of DHEA-S deficiency on mood or QOL.

引用

页数：8