A randomized trial of rizatriptan in migraine attacks in children

被引:69
作者
Ahonen, K.
Hamalainen, M. L.
Eerola, M.
Hoppu, K.
机构
[1] Univ Helsinki, Dept Clin Pharmacol, FIN-00290 Helsinki, Finland
[2] Univ Helsinki, Hosp Children & Adolescents, FIN-00290 Helsinki, Finland
[3] Univ Helsinki, Dept Math & Stat, FIN-00290 Helsinki, Finland
关键词
D O I
10.1212/01.wnl.0000238179.79888.44
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To examine the efficacy of rizatriptan and the consistency of treatment response in migraine attacks of children and adolescents. Methods: We conducted a double-blind, placebo-controlled three-way crossover trial in patients ages 6 to 17 years diagnosed with migraine in two pediatric hospital outpatient clinics. Two doses of rizatriptan and a matching placebo were administered at home during three attacks. Rizatriptan dose was 5 mg for those with a body weight of 20 to 39 kg, and 10 mg for those with a body weight of 40 kg or more. The primary efficacy endpoint was headache relief by two grades on a five-grade face scale at 2 hours. Results: Ninety-six patients used all three treatments, 10 used two, and 10 only the first. At 2 hours, the primary endpoint was reached twice as often after both treatments of rizatriptan (first 74%, n = 71/96; second 73%, n = 70/96) as after placebo (36%, n = 35/96) (p < 0.001). Already at 1 hour, rizatriptan was clearly more effective as headache relief was reported by 50% (n = 48/96) and 55% (n = 53/96) of children after the first and the second dose of rizatriptan, compared to 29% (n = 28/96) after placebo (p = 0.004). Rizatriptan was superior at 3 and 4 hours, and the other endpoints also favored rizatriptan. Efficacy of rizatriptan was constant over the two treated attacks, and the findings were similar in children using the dose of 5 and 10 mg. No serious adverse effects were observed. Conclusions: Oral rizatriptan is effective and well-tolerated for migraine attacks in children over age 6 years.
引用
收藏
页码:1135 / 1140
页数:6
相关论文
共 19 条
[1]   PREVALENCE OF HEADACHE AND MIGRAINE IN SCHOOLCHILDREN [J].
ABUAREFEH, I ;
RUSSELL, G .
BRITISH MEDICAL JOURNAL, 1994, 309 (6957) :765-769
[2]   Nasal sumatriptan is effective in treatment of migraine attacks in children -: A randomized trial [J].
Ahonen, K ;
Hämäläinen, ML ;
Rantala, H ;
Hoppu, K .
NEUROLOGY, 2004, 62 (06) :883-887
[3]   Efficacy and safety of rizatriptan versus standard care during long-term treatment for migraine [J].
Block, GA ;
Goldstein, J ;
Polis, A ;
Reines, SA ;
Smith, ME .
HEADACHE, 1998, 38 (10) :764-771
[4]   Pharmacokinetics of rizatriptan tablets during and between migraine attach [J].
Cutler, NR ;
Jhee, SS ;
Majumdar, AK ;
McLoughlin, D ;
Brucker, MJ ;
Carides, AD ;
Kramer, MS ;
Matzura-Wolfe, D ;
Reines, SA ;
Goldberg, MR .
HEADACHE, 1999, 39 (04) :264-269
[5]   Symptomatic treatment of migraine in children: A systematic review of medication trials [J].
Damen, L ;
Bruijn, JKJ ;
Verhagen, AP ;
Berger, MY ;
Passchier, J ;
Koes, BW .
PEDIATRICS, 2005, 116 (02) :E295-E302
[6]   Effect of encapsulation on absorption of sumatriptan tablets: Data from healthy volunteers and patients during a migraine [J].
Fuseau, E ;
Petricoul, O ;
Sabin, A ;
Pereira, A ;
O'Quinn, S ;
Thein, S ;
Leibowitz, M ;
Purdon, H ;
McNeal, S ;
Salonen, R ;
Metz, A .
CLINICAL THERAPEUTICS, 2001, 23 (02) :242-251
[7]   Efficacy and tolerability of rizatriptan 10 mg in migraine:: Experience with 70527 patient episodes [J].
Göbel, H ;
Heinze, A ;
Heinze-Kuhn, K ;
Lindner, V .
HEADACHE, 2001, 41 (03) :264-270
[8]   Sumatriptan for migraine attacks in children: A randomized placebo-controlled study - Do children with migraine respond to oral sumatriptan differently from adults? [J].
Hamalainen, ML ;
Hoppu, K ;
Santavuori, P .
NEUROLOGY, 1997, 48 (04) :1100-1103
[9]   Ibuprofen or acetaminophen for the acute treatment of migraine in children: A double-blind, randomized, placebo-controlled, crossover study [J].
Hamalainen, ML ;
Hoppu, K ;
Valkeila, E ;
Santavuori, P .
NEUROLOGY, 1997, 48 (01) :103-107
[10]  
*HEAD CLASS COMM I, 1988, CEPHALALGIA S7, V8