Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the essential oils from Piper arboreum Aubl., Piper aduncum L. e Piper gaudichaudianum Kunth

被引：14

作者：

da Silva, Ana Cristina A. ^{[3
]}

Matias, Edinardo F. F. ^{[3
]}

Rocha, Janaina E. ^{[3
]}

Justino de Araujo, Ana Carolina ^{[3
]}

de Freitas, Thiago S. ^{[3
]}

Campina, Fabia F. ^{[3
]}

Costa, Maria do S. ^{[3
]}

Silva, Luiz E. ^{[4
]}

do Amaral, Wanderlei ^{[4
]}

Maia, Beatriz Helena L. N. S. ^{[4
]}

Ferriani, Aurea P. ^{[4
]}

Bezerra, Camila F. ^{[5
]}

Iriti, Marcello ^{[1
]}

Coutinho, Henrique D. M. ^{[2
]}

机构：

[1] Milan State Univ, Dept Agr & Environm Sci, Via G Celoria, I-20133 Milan, Italy

[2] Univ Reg Cariri URCA, Lab Microbiol & Biol Mol LMBM, Av Cel Antonio Luiz 1161, BR-63105000 Crato, CE, Brazil

[3] Reg Univ Cariri URCA, Crato, CE, Brazil

[4] Fed Univ Parana UFPR, Curitiba, Parana, Brazil

[5] Fed Univ Pernambuco UFPE, Recife, PE, Brazil

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2021年 / 76卷 / 1-2期

关键词：

antibacterial activity; essential oil; modulation; Piperaceae; ANTIOXIDANT ACTIVITY; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; RESISTANCE; EFFLUX; LEAVES;

D O I：

10.1515/znc-2020-0045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this study was to determine the chemical profile and to evaluate the antibacterial activity of the essential oils of Piper species and modulation of the antibiotic activity, using the microdilution method to determine the minimum inhibitory concentration. The chemical components were characterized by gas chromatography coupled to mass spectrometry, which revealed beta-copaen-4-alpha-ol (31.38%), spathulenol (25.92%), and germacrene B (21.53%) as major constituents of the essential oils of Piper arboreum, Piper aduncum, and Piper gaudichaudianum, respectively. The essential oils analyzed in this study did not present a clinically relevant activity against standard and multiresistant Escherichia coli. However, in the case of multiresistant Staphylococcus aureus, there was a significant activity, corroborating with reports in the literature, where Gram-positive bacteria are more susceptible to antimicrobial activity. The essential oils modulated the effect of the antibiotics norfloxacin and gentamicin, having on the latter greater modulating effect; however, for erythromycin, no statistically significant effect was observed. In conclusion, the results obtained in this study demonstrated that the essential oils of the analyzed Piper species present an inhibitory effect against S. aureus and modulate antibiotic activity, most of which presents synergistic activity.

引用

页码：35 / 42

页数：8

共 22 条

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[22] GC-MS Analysis and Evaluation of Antibacterial and Antifungal Activity of Essential Oils Extracted From Fruit Peel of Citrus aurantium L. (Rutaceae) Grown in the West Anatolian Area; [GC-MS-Analyse und Beurteilung der bakteriziden und fungiziden Wirkungen von ätherischen Ölen, gewonnen aus Fruchtschalen von Citrus aurantium L. (Rutaceae), angebaut in der Provinz West-Anatolien]
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