Penetration Enhancers in Ocular Drug Delivery

被引：144

作者：

Moiseev, Roman, V ^{[1
]}

Morrison, Peter W. J. ^{[1
]}

Steele, Fraser ^{[2
]}

Khutoryanskiy, Vitaliy V. ^{[1
]}

机构：

[1] Univ Reading, Reading Sch Pharm, POB 224, Reading RG6 6AD, Berks, England

[2] MC2 Therapeut, James House,Emlyn Lane, Leatherhead KT22 7EP, Surrey, England

来源：

PHARMACEUTICS | 2019年 / 11卷 / 07期

关键词：

ocular drug delivery; cornea; penetration enhancers; ocular conditions; ophthalmology; VITRO CORNEAL PERMEABILITY; CROWN-ETHERS; IN-VITRO; POSTERIOR SEGMENT; BENZALKONIUM CHLORIDE; TOPICAL DELIVERY; HYDROPHILIC COMPOUNDS; PERMEATION ENHANCERS; ABSORPTION ENHANCER; RABBIT CORNEAS;

D O I：

10.3390/pharmaceutics11070321

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes. This review paper provides an overview of anatomical and physiological features of the eye and discusses some common ophthalmological conditions and permeability of ocular membranes. The review also presents the analysis of literature on the use of penetration-enhancing compounds (cyclodextrins, chelating agents, crown ethers, bile acids and bile salts, cell-penetrating peptides, and other amphiphilic compounds) in ocular drug delivery, describing their properties and modes of action.

引用

页数：33

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