B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling
被引:178
作者:
Fan, Lina
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Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Fan, Lina
[1
,2
]
Qi, Yadong
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Qi, Yadong
[1
,2
]
Qu, Siwen
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Qu, Siwen
[1
,2
]
Chen, Xueqin
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Chen, Xueqin
[1
,2
]
Li, Aiqing
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Li, Aiqing
[1
,2
]
Hendi, Maher
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Hendi, Maher
[3
]
Xu, Chaochao
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Xu, Chaochao
[1
,2
]
Wang, Lan
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Wang, Lan
[1
,2
]
Hou, Tongyao
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机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Hou, Tongyao
[1
,2
]
Si, Jianmin
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机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Si, Jianmin
[1
,2
]
Chen, Shujie
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h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
Chen, Shujie
[1
,2
]
机构:
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 Qingchun East Rd, Hangzhou 310016, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Gastroenterol, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China
Inflammatory bowel disease (IBD) is defined as an immune dysregulation disease with poor prognosis. Various therapies based on gut microbe modulation have been proposed. In this study, we aim to explore the therapeutic effect of B. adolescentis on IBD, as well as the immune and microecology mechanism of B. adolescentis in IBD. The fecal level of B. adolescentis was decreased in the IBD patients compared with the normal people in our cohort and the GMrepo database. To further clarify the role of B. adolescentis in IBD, we induced chronic colitis with three cycles of dextran sulfate sodium (DSS). We found B. adolescentis gavage exhibited protective effects as evidenced by the significantly decreased diarrhea score, spleen weight, and increased colon length. Accordingly, the cumulative histological grading was decreased in the B. adolescentis administration group. In addition, tight junction protein and mucin family were enhanced after B. adolescentis treatment. Furthermore, distinct effects were found with decreased pro-inflammatory cytokines such as TNF-alpha, IL-6, IL-1 beta, IL-18, IL-22, IL-9 and increased anti-inflammatory cytokines IL-10, IL-4, IL-5. Importantly, the colon lamina propria in the B. adolescentis group consisted of more Treg and Th2 cells, which inhibited extreme gut inflammation. Additionally, 16srRNA sequencing showed an evident increase in the B:F ratio in the B. adolescentis group. In particular, B. adolescentis application inhibited the excessive growth of Akkermansia and Escherichia-Shigella in genus level. In conclusion, B. adolescentis refined the DSS-induced chronic colitis by stimulating protective Treg/Th2 response and gut microbiota remodeling. B. adolescentis regularly treatment might improve the therapeutic effects for inflammatory bowel disease.
机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Ashida, Hiroshi
;
Ogawa, Michinaga
论文数: 0引用数: 0
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机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Ogawa, Michinaga
;
Kim, Minsoo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Infect Dis Control, Int Res Ctr Infect Dis, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Kim, Minsoo
;
Mimuro, Hitomi
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机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Mimuro, Hitomi
;
Sasakawa, Chihiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Univ Tokyo, Inst Med Sci, Dept Infect Dis Control, Int Res Ctr Infect Dis, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
机构:
Univ Paris 05, INSERM, U989, F-75730 Paris 15, France
INRA, UM1319, F-78350 Jouy En Josas, FranceUniv Paris 05, INSERM, U989, F-75730 Paris 15, France
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Chen, Liping
;
Wang, Wei
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机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Wang, Wei
;
Zhou, Rui
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h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Zhou, Rui
;
Ng, Siew C.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Ng, Siew C.
;
Li, Jin
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Li, Jin
;
Huang, Meifang
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Huang, Meifang
;
Zhou, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Zhou, Feng
;
Wang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian 710032, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
机构:
St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, AustraliaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Kamm, Michael A.
;
Wu, Kaichun
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian 710032, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Wu, Kaichun
;
Xia, Bing
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Hubei Clin Ctr, Wuhan, Peoples R China
Key Lab Intestinal & Colorectal Dis, Wuhan, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
机构:
Univ Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, Italy
Compare, Debora
;
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机构:
Rocco, Alba
;
Zamparelli, Marco Sanduzzi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, Italy
机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Ashida, Hiroshi
;
Ogawa, Michinaga
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Ogawa, Michinaga
;
Kim, Minsoo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Infect Dis Control, Int Res Ctr Infect Dis, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Kim, Minsoo
;
Mimuro, Hitomi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Mimuro, Hitomi
;
Sasakawa, Chihiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
Univ Tokyo, Inst Med Sci, Dept Infect Dis Control, Int Res Ctr Infect Dis, Tokyo, JapanUniv Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Tokyo, Japan
机构:
Univ Paris 05, INSERM, U989, F-75730 Paris 15, France
INRA, UM1319, F-78350 Jouy En Josas, FranceUniv Paris 05, INSERM, U989, F-75730 Paris 15, France
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Chen, Liping
;
Wang, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Wang, Wei
;
Zhou, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Zhou, Rui
;
Ng, Siew C.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Ng, Siew C.
;
Li, Jin
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Li, Jin
;
Huang, Meifang
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Huang, Meifang
;
Zhou, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Zhou, Feng
;
Wang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian 710032, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
机构:
St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, AustraliaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Kamm, Michael A.
;
Wu, Kaichun
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian 710032, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Wu, Kaichun
;
Xia, Bing
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
Hubei Clin Ctr, Wuhan, Peoples R China
Key Lab Intestinal & Colorectal Dis, Wuhan, Peoples R ChinaWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Peoples R China
机构:
Univ Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, Italy
Compare, Debora
;
论文数: 引用数:
h-index:
机构:
Rocco, Alba
;
Zamparelli, Marco Sanduzzi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Hepatogastroenterol Unit, Via S Pansini 5, IT-80131 Naples, Italy