The role of the VEGF-C/VEGFR-3 axis in cancer progression

被引：217
作者：
Su, J-L
Yen, C-J
Chen, P-S
Chuang, S-E
Hong, C-C
Kuo, I-H
Chen, H-Y
Hung, M-C
Kuo, M-L
机构：
[1] Natl Taiwan Univ, Coll Med, Inst Toxicol, Lab Mol & Cellular Toxicol, Taipei, Taiwan
[2] Natl Hlth Res Inst, Div Canc Res, Taipei 10016, Taiwan
[3] Univ Texas, Hlth Sci Ctr, Grad Sch Biomed Sci, Houston, TX 77030 USA
[4] Natl Taiwan Univ, Angiogenesis Res Ctr, Taipei, Taiwan
[5] Natl Cheng Kung Univ Hosp, Inst Clin Med, Tainan 70428, Taiwan
[6] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan
[7] Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
[8] Asia Univ, Dept Biotechnol & Bioinformat, Taichung 41354, Taiwan
[9] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan
[10] China Med Univ, Coll Med, Inst Med Sci, Taichung 404, Taiwan
来源：
BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 04期
关键词：
VEGF-C; VEGFR-3; lymphangiogenesis; metastasis;
D O I：
10.1038/sj.bjc.6603487
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.
引用
收藏
页码：541 / 545
页数：5
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