Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver

被引：1667

作者：

Lu, Yifeng ^{[1
]}

Zhang, Yan ^{[1
]}

Deng, Yongfeng ^{[1
]}

Jiang, Wei ^{[1
]}

Zhao, Yanping ^{[2
]}

Geng, Jinju ^{[1
]}

Ding, Lili ^{[1
]}

Ren, Hongqiang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Normal Univ, Sch Geog Sci, Jiangsu Key Lab Environm Change & Ecol Construct, Nanjing 210023, Jiangsu, Peoples R China

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2016年 / 50卷 / 07期

基金：

中国国家自然科学基金;

关键词：

GOBY POMATOSCHISTUS-MICROPS; CHAIN AMINO-ACIDS; ENERGY-METABOLISM; FOOD-INTAKE; MARINE; NANOPARTICLES; POLLUTANTS; PARTICLES; INGESTION; RESPONSES;

D O I：

10.1021/acs.est.6b00183

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 mu m diameter MPs accumulated in fish gills, liver, and gut, while 20 mu m diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 mu m and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that, oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.

引用

页码：4054 / 4060

页数：7

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