More than Meets the Eye: the Relationship between Pupil Size and Locus Coeruleus Activity

被引:78
作者
Costa, Vincent D. [1 ]
Rudebeck, Peter H. [2 ]
机构
[1] NIMH, Bethesda, MD 20814 USA
[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
关键词
AROUSAL; ACTIVATION; NEURONS; MONKEYS; BRAIN; GAIN;
D O I
10.1016/j.neuron.2015.12.031
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Using both direct neural recordings and electrical microstimulation, Joshi et al. (2016) show that locus coeruleus (LC) activity closely matches moment-to-moment changes in pupil size. But what causes these two measures to be related is not straightforward.
引用
收藏
页码:8 / 10
页数:3
相关论文
共 12 条
[1]  
An X, 1998, J COMP NEUROL, V401, P455
[2]   An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance [J].
Aston-Jones, G ;
Cohen, JD .
ANNUAL REVIEW OF NEUROSCIENCE, 2005, 28 :403-450
[3]   The pupil as a measure of emotional arousal and autonomic activation [J].
Bradley, Margaret M. ;
Miccoli, Laura ;
Escrig, Miguel A. ;
Lang, Peter J. .
PSYCHOPHYSIOLOGY, 2008, 45 (04) :602-607
[4]   Tuning arousal with optogenetic modulation of locus coeruleus neurons [J].
Carter, Matthew E. ;
Yizhar, Ofer ;
Chikahisa, Sachiko ;
Nguyen, Hieu ;
Adamantidis, Antoine ;
Nishino, Seiji ;
Deisseroth, Karl ;
de Lecea, Luis .
NATURE NEUROSCIENCE, 2010, 13 (12) :1526-U117
[5]   The effects of neural gain on attention and learning [J].
Eldar, Eran ;
Cohen, Jonathan D. ;
Niv, Yael .
NATURE NEUROSCIENCE, 2013, 16 (08) :1146-U236
[6]  
ENNIS M, 1988, J NEUROSCI, V8, P3644
[7]   Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex [J].
Joshi, Siddhartha ;
Li, Yin ;
Kalwani, Rishi M. ;
Gold, Joshua I. .
NEURON, 2016, 89 (01) :221-234
[8]   Rational regulation of learning dynamics by pupil-linked arousal systems [J].
Nassar, Matthew R. ;
Rumsey, Katherine M. ;
Wilson, Robert C. ;
Parikh, Kinjan ;
Heasly, Benjamin ;
Gold, Joshua I. .
NATURE NEUROSCIENCE, 2012, 15 (07) :1040-1046
[9]   A role for primate subgenual cingulate cortex in sustaining autonomic arousal [J].
Rudebeck, Peter H. ;
Putnam, Philip T. ;
Daniels, Teresa E. ;
Yang, Tianming ;
Mitz, Andrew R. ;
Rhodes, Sarah E. V. ;
Murray, Elisabeth A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (14) :5391-5396
[10]   Distribution of norepinephrine transporters in the non-human primate brain [J].
Smith, HR ;
Beveridge, TJR ;
Porrino, LJ .
NEUROSCIENCE, 2006, 138 (02) :703-714