Part -IV: Utilities of active methylene compounds and heterocycles bearing active methyl or having an active methine in the synthesis of triazoles, pyridazines, triazines and diazepines

被引:3
作者
Abdel-Megid, Mohamed [1 ,2 ]
机构
[1] Ain Shams Univ, Dept Chem, Fac Educ, Cairo, Egypt
[2] Shaqra Univ, Coll Sci & Humanities Hurymmila, Shaqraa, Saudi Arabia
关键词
Active methylene; triazoles; pyridazines; triazines; diazepines; biological importance;
D O I
10.1080/00397911.2020.1865404
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Common and novel synthesized active methylene compounds as well as heterocycles bearing active methyl or having an active methine were used in the syntheses of a wide variety of substituted and fused five-, six- and seven-membered nitrogenous heterocyclic systems of interesting medical and pharmaceutical importance such as triazoles, pyridazines, triazines, and diazepines. Carbothiosemicarbazides, carbothiohydrazones and 2-hydrazinoazaherterocycles were used as suitable starting materials for triazole formation. The preparation of tetrazoles showed a valence ring-chain tautomerism. The key starting materials for the synthesis of pyridazines were acetohydrazide derivative, activated enones, enaminones, and aryl hydrazones. The reaction of 2-chloro or 2-hydrazinoazaheterocycles and thiocarbohydrazones with different reagents under suitable reaction conditions led to the formation of triazines. Diazepines were obtained via treatment of enones with 1,2-diamino derivatives. Also, the antimicrobial activities of some selected synthesized heterocyclic compounds were reported.
引用
收藏
页码:971 / 996
页数:26
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