An Efficient Three-Component Synthesis of 3-(1-Hydroxyalkyl)[1,2,4]-triazolo[4,3-c]quinazolines

被引：25
作者：
Adib, Mehdi [1 ]
Ansari, Samira [1 ]
Feizi, Shahzad [1 ]
Bijanzadeh, Hamid Reza [2 ]
机构：
[1] Univ Tehran, Sch Chem, Univ Coll Sci, Tehran, Iran
[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
SYNLETT | 2010年 / 06期
关键词：
N-isocyaniminotriphenylphosphorane; 4(3H)-quinazolinones; aldehydes; 3-(1-hydroxyalkyl)[1,2,4]triazolo[4,3-c]quinazolines; multicomponent reactions; cyclizations; heterocycles; ONE-POT; MULTICOMPONENT REACTIONS; MICROWAVE IRRADIATION; ACID-DERIVATIVES; (N-ISOCYANIMINO)TRIPHENYLPHOSPHORANE; GROWTH;
D O I：
10.1055/s-0029-1219562
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient three-component synthesis of 3-(1-hydroxyalkyl)[1,2,4] triazolo[4,3-c] quinazolines is described. A mixture of N-isocyaniminotriphenylphosphorane, an aldehyde, and a 4(3H)quinazolinone undergo a 1:1:1 addition reaction in refluxing THF to afford the title compounds in good to excellent yields.
引用
收藏
页码：921 / 923
页数：3
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