Recent advances in angiogenesis, anti-angiogenesis and vascular targeting

被引：112
作者：
Bikfalvi, A [1 ]
Bicknell, R
机构：
[1] Univ Bordeaux 1, INSERM, E 0133, Mol Mech Angiogenesis & Growth Factor & Cell Diff, Bordeaux, France
[2] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK,Mol Angiogenesis Lab, Oxford, England
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 12期
关键词：
D O I：
10.1016/S0165-6147(02)02109-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Angiogenesis, the development of new blood vessels, has become a major focus of research. This has been stimulated by the therapeutic opportunities offered by the ability to manipulate the vasculature in pathologies such as cancer. Here, we present an overview of recent advances in angiogenesis. Especially noteworthy is the large volume of information from developmental studies, particularly those that involve transgenic and gene knockout mice. We also discuss the increasing repertoire of drugs with which to manipulate angiogenesis and new endothelial-specific genes with which to target the vasculature.
引用
收藏
页码：576 / 582
页数：7
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