Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review

被引：141
作者：
Leung, Lawrence [1 ]
Birtwhistle, Richard [1 ]
Kotecha, Jyoti [1 ]
Hannah, Susan [1 ]
Cuthbertson, Sharon [1 ]
机构：
[1] Queens Univ, Ctr Studies Primary Care, Dept Family Med, Kingston, ON K7L 5E9, Canada
来源：
BRITISH JOURNAL OF NUTRITION | 2009年 / 102卷 / 12期
关键词：
Momordica charantia; Hyoglycaemic agents; Diabetes mellitus; Complementary and alternative medicine; GLUCOSE-TOLERANCE; POSTPRANDIAL HYPERGLYCEMIA; DIABETES-MELLITUS; GLYCEMIC CONTROL; FRUIT PULP; INSULIN; EXTRACT; PLANT; RATS; TRITERPENOIDS;
D O I：
10.1017/S0007114509992054
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. Momordica charantia (bitter melon) is a popular fruit used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. Abundant pre-clinical studies have documented the anti-diabetic and hypoglycaemic effects of M. charantia through various postulated mechanisms. However, clinical trial data with human Subjects are limited and flawed by poor study design and low statistical power. The present article reviews the clinical data regarding the anti-diabetic potentials of M. charantia and calls for better-designed clinical trials to further elucidate its possible therapeutic effects.
引用
收藏
页码：1703 / 1708
页数：6
相关论文
共 57 条
  • [1] Abascal K., 2005, Alternative and complementary therapies, V11, P179, DOI DOI 10.1089/ACT.2005.11.179
  • [2] Ahmad N, 1999, Bangladesh Med Res Counc Bull, V25, P11
  • [3] Akhtar M S, 1982, J Pak Med Assoc, V32, P106
  • [4] STUDIES ON HYPOGLYCEMIC EFFECTS OF FRUIT PULP, SEED, AND WHOLE-PLANT OF MOMORDICA-CHARANTIA ON NORMAL AND DIABETIC MODEL RATS
    ALI, L
    KHAN, AKA
    MAMUN, MIR
    MOSIHUZZAMAN, M
    NAHAR, N
    NUREALAM, M
    ROKEYA, B
    [J]. PLANTA MEDICA, 1993, 59 (05) : 408 - 412
  • [5] CLINICAL-TRIAL IN PATIENTS WITH DIABETES-MELLITUS OF AN INSULIN-LIKE COMPOUND OBTAINED FROM PLANT SOURCE
    BALDWA, VS
    BHANDARI, CM
    PANGARIA, A
    GOYAL, RK
    [J]. UPSALA JOURNAL OF MEDICAL SCIENCES, 1977, 82 (01) : 39 - 41
  • [6] Balkau B, 2000, DIABETES METAB, V26, P282
  • [7] Cefalu William T., 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P78, DOI 10.2174/187153008784534376
  • [8] Postprandial hyperglycemia and diabetes complications - Is it time to treat?
    Ceriello, A
    [J]. DIABETES, 2005, 54 (01) : 1 - 7
  • [9] THE TERMINATION OF EARLY-PREGNANCY IN THE MOUSE BY BETA-MOMORCHARIN
    CHAN, WY
    TAM, PPL
    YEUNG, HW
    [J]. CONTRACEPTION, 1984, 29 (01) : 91 - 100
  • [10] Cucurbitane-type triterpenoids from the stems of Momordica charantia
    Chang, Chi-I
    Chen, Chiy-Rong
    Liao, Yun-Wen
    Cheng, Hsueh-Ling
    Chen, Yo-Chia
    Chou, Chang-Hung
    [J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (08): : 1327 - 1330
123456