Iron-Catalyzed Inexpensive and Practical Synthesis of N-Substituted Pyrroles in Water

被引：92
作者：
Azizi, Najmedin [1 ]
Khajeh-Amiri, Alireza [1 ]
Ghafuri, Hossein [2 ]
Bolourtchian, Mohammad [1 ]
Saidi, Mohammad Reza [2 ]
机构：
[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran
[2] Sharif Univ Technol, Dept Chem, Tehran 11365, Iran
来源：
SYNLETT | 2009年 / 14期
关键词：
dimethoxytetrahydrofuran; iron; pyrrole; amine; water chemistry; SOLID-PHASE SYNTHESIS; ONE-POT SYNTHESIS; SOLVENT-FREE; INDOLES; CONDENSATION; PRECURSORS; ALKYLATION; ALKYNES; AMINES;
D O I：
10.1055/s-0029-1217799
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An operationally simple, practical, and economical protocol for iron(III) chloride catalyzed Paal-Knorr pyrrole synthesis in water in good to excellent yields has been developed. Several N-substituted pyrroles are readily prepared from the reaction of 2,5-dimethoxytetrahydrofuran and aryl/alkyl, sulfonyl and acyl amines under very mild reaction conditions
引用
收藏
页码：2245 / 2248
页数：4
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