Antifungal activity of extracts from Cynomorium coccineum growing wild in Sardinia island (Italy)

被引：12

作者：

Goncalves, Maria Jose ^{[1
,2
]}

Piras, Alessandra ^{[3
]}

Porcedda, Silvia ^{[3
]}

Marongiu, Bruno ^{[3
]}

Falconieri, Danilo ^{[4
]}

Cavaleiro, Carlos ^{[1
,2
]}

Rescigno, Antonio ^{[5
]}

Rosa, Antonella ^{[5
]}

Salgueiro, Ligia ^{[1
,2
]}

机构：

[1] Univ Coimbra, Fac Farm, CEF, P-3000548 Coimbra, Portugal

[2] Univ Coimbra, CNC, P-3000548 Coimbra, Portugal

[3] Univ Cagliari, Dipartimento Sci Chim & Geol, SS 554,Km 4,500, I-09042 Monserrato, Italy

[4] Ist Tecn Ind Statale Michele Giua, I-09100 Cagliari, Italy

[5] Univ Cagliari, Dipartimento Sci Biomed, I-09042 Monserrato, Italy

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 23期

关键词：

Cynomorium coccineum; methanolic extract; antifungal activity; candidiasis; cryptococcosis; IMMATURE WISTAR RATS; WITHANIA-SOMNIFERA; ESSENTIAL OIL; CRYPTOCOCCUS; ASPERGILLUS; CANDIDA;

D O I：

10.1080/14786419.2014.1000892

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cynomorium coccineum L. is a non-photosynthetic plant, spread over Mediterranean countries, amply used in traditional medicine. The aim of this study was to evaluate for the first time the antifungal activity of its extracts. The antifungal activity was evaluated using the macrodilution method against Candida spp., Cryptococcus neoformans and dermatophyte strains. The methanolic extract was very active against C. neoformans, Candida guilliermondii and Candida krusei, with minimal inhibitory concentrations (MIC) values of 0.025 mg/mL. This extract is more active than fluconazole against C. krusei H9. The influence of methanolic extract on the dimorphic transition in Candida albicans was also studied through the germ tube inhibition assay. More than 60% of filamentation was inhibited at a concentration of 1/4 MIC. These results are preliminary and further studies are needed to an eventual use of C. coccineum methanolic extract in the treatments of candidiasis and cryptococcosis.

引用

页码：2247 / 2250

页数：4

共 14 条

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