Ganoderma lucidum repress injury of ethanol-induced steatohepatitis via anti-inflammation, anti-oxidation and reducing hepatic lipid in C57BL/6J mice

被引：27

作者：

Chung, Dai-Jung ^{[1
]}

Yang, Mon-Yuan ^{[1
]}

Li, Yi-Ru ^{[2
]}

Chen, Wei-Jen ^{[4
]}

Hung, Chiu-Ya ^{[5
]}

Wang, Chau-Jong ^{[1
,3
]}

机构：

[1] Chung Shan Med Univ, Inst Biochem Microbiol & Immunol, 110,Sect 1,Jiankuo North Rd, Taichung 402, Taiwan

[2] Chung Shan Med Univ Hosp, Dept Internal Med, 110,Sect 1,Jiankuo North Rd, Taichung 402, Taiwan

[3] Chung Shan Med Univ Hosp, Dept Med Res, 110,Sect 1,Jiankuo North Rd, Taichung 402, Taiwan

[4] Syngen Biotech Co Ltd, Chairmans Off, Tainan, Taiwan

[5] Syngen Biotech Co Ltd, Res & Dev Dept, Tainan, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2017年 / 33卷

关键词：

Ganoderma submerged fermentation; Alcohol-induced liver injury; Antioxidant; Lipid accumulation; LIVER-INJURY; FATTY LIVER; POLYSACCHARIDES; MECHANISM; PATHOGENESIS; ANTITUMOR; ALCOHOL; CELLS;

D O I：

10.1016/j.jff.2017.03.059

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Ganoderma lucidum has been well recognized as medical herb, which is effective on antitumor, inhibition of lipid peroxidation and downregulation blood-pressure. The aquatic extract of Ganoderma lucidum has many bioactive substances, such as polysaccharides, triterpenes and polysaccharide-peptide complex. However, these curative effects and effective ingredients are fewer known in ethanol-induced fatty liver. In this study, Ganoderma Submerged Fermentation (GSF), the commercial Ganoderma products were investigated treatment in prevention of alcohol-induced liver injury in mice. GLP showed potent antioxidant activities and declined lipid accumulation in ethanol-induced mice, such as liver injury biomarkers (AST, ALT and ALP), triglyceride (TG) and cholesterol (TC) in plasma and hepatic content. Moreover, treatment of GSF calmed the inflammation element expression, including iNOS, COX2, TNF-alpha NF-kappa B and IL-6. On the basis of these results, GSF from Ganoderma lucidum possesses potential on anti-oxidant, anti inflammation, and reduced lipid accumulation in alcoholic liver disease. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：314 / 322

页数：9

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