A cytotoxic constituent from Sophora flavescens

被引：19
作者：
Kim, YK [1 ]
Min, BS [1 ]
Bae, KH [1 ]
机构：
[1] CHUNGNAM NATL UNIV,COLL PHARM,TAEJON 305764,SOUTH KOREA
来源：
ARCHIVES OF PHARMACAL RESEARCH | 1997年 / 20卷 / 04期
关键词：
Sophora flavescens; Sophora moorcroftiang; Leguminosae; sophoraflavanone G; cytotoxicity; A549;
D O I：
10.1007/BF02976197
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A cytotoxic constituent was isolated by bioassay-guided procedure from the roots of Sophora flavescens Aiton (Leguminosae). The constituent was identified as sophoraflavanone G (I) by means of chemical methods and in comparsion with spectral data of standard compound. The ED50 values of constituent I were 0.78, 1.57, 2.14 and 8.59 mu g/ml against A549, HeLa, K562 and L1210 cell lines, respectively. Constituent I exhibited highly cytotoxic activities against A 549, K562 and HeLa cells, but showed a mild activity (ED50 value, 5 mu g/ml) against L1210 cells. Among the tested cell lines, A549 cells were the most sensitive to constituent I.
引用
收藏
页码：342 / 345
页数：4
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