Circadian variation in acute myocardial infarct size assessed by cardiovascular magnetic resonance in reperfused STEMI patients

被引:32
作者
Bulluck, Heerajnarain [1 ]
Nicholas, Jennifer [2 ,4 ,5 ,6 ]
Crimi, Gabriele [4 ,7 ,8 ]
White, Steven K. [1 ,4 ,5 ,6 ,7 ,9 ]
Ludman, Andrew J. [4 ,5 ,6 ,7 ]
Pica, Silvia [1 ,2 ,3 ]
Raineri, Claudia [2 ,3 ,8 ,9 ]
Cabrera-Fuentes, Hector A. [8 ,9 ]
Yellona, Derek
Rodriguez-Palomares, Jose
Garcia-Dorado, David
Hausenloy, Derek J. [1 ]
机构
[1] UCL, Hatter Cardiovasc Inst, Inst Cardiovasc Sci, London, England
[2] UCL, Natl Inst Hlth Res, Hosp Biomed Res Ctr, London, England
[3] UCL, Natl Inst Hlth Res, Hosp Biomed Res Ctr, London, England
[4] Royal Devon & Exeter Hosp NHS Fdn Trust, Exeter, Devon, England
[5] Fdn Ist Ricovero Cura Carattere Sci, Struttura Complessa Cardiol, Pavia, Italy
[6] Univ Autonoma Barcelona, Vall dHebron Hosp, Dept Cardiol, Barcelona, Spain
[7] Justus Liebig Univ, Inst Biochem, Sch Med, Giessen, Germany
[8] Natl Heart Res Inst Singapore, Natl Heart Ctr Singapore, Singapore, Singapore
[9] Duke Natl Univ Singapore, Cardiovasc & Metab Disorders Program, Singapore, Singapore
关键词
ST-segment elevation myocardial infarction; Circadian rhythm; Myocardial infarct size; Cardiovascular magnetic resonance; PERCUTANEOUS CORONARY INTERVENTION; LEFT-VENTRICULAR FUNCTION; QUANTITATIVE-ANALYSIS; HEART-RATE; ECHOCARDIOGRAPHY; REPRODUCIBILITY; DEPENDENCE; RHYTHM; RISK; TIME;
D O I
10.1016/j.ijcard.2016.12.030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Clinical studies using serum cardiac biomarkers to investigate a circadian variation in acute myocardial infarct (MI) size in ST-segment elevation myocardial infarction (STEMI) patients reperfused by primary percutaneous coronary intervention (PPCI) have produced mixed results. We aimed to investigate this phenomenon using acute MI size measured by cardiovascular magnetic resonance (CMR). Methods: Patient-level data was obtained from 4 randomized controlled trials investigating the MI-limiting effects of cardioprotective therapies in this pooled analysis. The primary analysis was performed in those patients with no pre-infarct angina; duration of ischemia >60 min and <360 min; Thrombolysis In Myocardial Infarction (TIMI) flow pre-PPCI <= 1; TIMI flow post-PPCI 3; and no collateral flow. Results: 169 out of 376 patients with CMR data met the inclusion criteria for the primary analysis. A 24-hour circadian variation in acute MI size as a % of the area-at-risk (%AAR), after adjusting for confounders, was observed with a peak and nadir MI size in patients with symptom onset between 00:00 and 01:00 and between 12:00 and 13:00 respectively (difference from the average MI size 5.2%, 95%CI 1.19.4%; p = 0.013). This was associated with a non-significant circadian variation in left ventricular ejection fraction (LVEF) (difference from the average LVEF 5.9%, 95%CI - 0.62.2%, p = 0.073). There was no circadian variation in MI size or LVEF in the whole cohort. Conclusions: We report a circadian variation in acute MI size assessed by CMR in a subset of STEMI patients treated by PPCI, with the largest and smallest MI size occurring in patients with symptom onset between 00:00 and 01:00 and between 12:00 and 13:00 respectively. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
引用
收藏
页码:149 / 154
页数:6
相关论文
共 34 条
[1]   Questing for Circadian Dependence in ST-Segment-Elevation Acute Myocardial Infarction A Multicentric and Multiethnic Study [J].
Ammirati, Enrico ;
Cristell, Nicole ;
Cianflone, Domenico ;
Vermi, Anna-Chiara ;
Marenzi, Giancarlo ;
De Metrio, Monica ;
Uren, Neal G. ;
Hu, Dayi ;
Ravasi, Timothy ;
Maseri, Attilio ;
Cannistraci, Carlo V. .
CIRCULATION RESEARCH, 2013, 112 (10) :E110-E114
[2]  
Apple FS, 1996, AM J CLIN PATHOL, V105, P6
[3]   Circadian Rhythm of Infarct Size and Left Ventricular Function Evaluated with Tissue Doppler Echocardiography in ST Elevation Myocardial Infarction [J].
Ari, Hatem ;
Sonmez, Osman ;
Koc, Fatih ;
Demir, Kenan ;
Alihanoglu, Yusuf ;
Ozdemir, Kurtulus ;
Vatankulu, Mehmet Akif .
HEART LUNG AND CIRCULATION, 2016, 25 (03) :250-256
[4]   Influence of diurnal variation in the size of acute myocardial infarction [J].
Arroyo Ucar, E. ;
Dominguez-Rodriguez, A. ;
Abreu-Gonzalez, P. .
MEDICINA INTENSIVA, 2012, 36 (01) :11-14
[5]   T1 mapping and T2 mapping at 3T for quantifying the area-at-risk in reperfused STEMI patients [J].
Bulluck, Heerajnarain ;
White, Steven K. ;
Rosmini, Stefania ;
Bhuva, Anish ;
Treibel, Thomas A. ;
Fontana, Marianna ;
Abdel-Gadir, Amna ;
Herrey, Anna ;
Manisty, Charlotte ;
Wan, Simon M. Y. ;
Groves, Ashley ;
Menezes, Leon ;
Moon, James C. ;
Hausenloy, Derek J. .
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2015, 17
[6]   A QUANTITATIVE-ANALYSIS OF THE EFFECTS OF ACTIVITY AND TIME OF DAY ON THE DIURNAL-VARIATIONS OF BLOOD-PRESSURE [J].
CLARK, LA ;
DENBY, L ;
PREGIBON, D ;
HARSHFIELD, GA ;
PICKERING, TG ;
BLANK, S ;
LARAGH, JH .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (07) :671-681
[7]  
Cox N.J., 2006, STATA J, V6
[8]   Remote Ischemic Post-Conditioning of the Lower Limb During Primary Percutaneous Coronary Intervention Safely Reduces Enzymatic Infarct Size in Anterior Myocardial Infarction A Randomized Controlled Trial [J].
Crimi, Gabriele ;
Pica, Silvia ;
Raineri, Claudia ;
Bramucci, Ezio ;
De Ferrari, Gaetano M. ;
Klersy, Catherine ;
Ferlini, Marco ;
Marinoni, Barbara ;
Repetto, Alessandra ;
Romeo, Maurizio ;
Rosti, Vittorio ;
Massa, Margherita ;
Raisaro, Arturo ;
Leonardi, Sergio ;
Rubartelli, Paolo ;
Visconti, Luigi Oltrona ;
Ferrario, Maurizio .
JACC-CARDIOVASCULAR INTERVENTIONS, 2013, 6 (10) :1055-1063
[9]   Histone acetyltransferase-dependent chromatin remodeling and the vascular clock [J].
Curtis, AM ;
Seo, SB ;
Westgate, EJ ;
Rudic, RD ;
Smyth, EM ;
Chakravarti, D ;
FitzGerald, GA ;
McNamara, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (08) :7091-7097
[10]   An historical approach to the diagnostic biomarkers of acute coronary syndrome [J].
Danese, Elisa ;
Montagnana, Martina .
ANNALS OF TRANSLATIONAL MEDICINE, 2016, 4 (10)