Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

被引：171

作者：

Eyers, Patrick A. ^{[1
]}

Keeshan, Karen ^{[2
]}

Kannan, Natarajan ^{[3
,4
]}

机构：

[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool L69 7ZB, Merseyside, England

[2] Univ Glasgow, Coll Med Vet & Life Sci, Inst Canc Sci, Paul OGorman Leukemia Res Ctr, Glasgow G12 0YN, Lanark, Scotland

[3] Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA

[4] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

来源：

TRENDS IN CELL BIOLOGY | 2017年 / 27卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

C/EBP-ALPHA; GENE-EXPRESSION; FUNCTIONAL DIVERGENCE; MEDIATES DEATH; BREAST-CANCER; KINASE DOMAIN; TAL1; COMPLEX; BETA-TRCP; TRIB2; CLASSIFICATION;

D O I：

10.1016/j.tcb.2016.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and evolved unique features distinguishing them from all other protein kinases. The atypical pseudokinase domain retains a regulated binding platform for substrates, which are ubiquitinated by context-specific E3 ligases. This plastic configuration has also been exploited as a scaffold to support the modulation of canonical MAPK and AKT modules. In this review, we discuss the evolution of TRIBs and their roles in vertebrate cell biology. TRIB2 is the most ancestral member of the family, whereas the emergence of TRIB3 homologs in mammals supports additional biological roles, many of which are currently being dissected. Given their pleiotropic role in diseases, the unusual TRIB pseudokinase conformation provides a highly attractive opportunity for drug design.

引用

页码：284 / 298

页数：15

共 96 条

[61] TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism [J].

Qi, Ling ;

Heredia, Jose E. ;

Altarejos, Judith Y. ;

Screaton, Robert ;

Goebel, Naomi ;

Niessen, Sherry ;

MacLeod, Ian X. ;

Liew, Chong Wee ;

Kulkarni, Rohit N. ;

Bain, James ;

Newgard, Christopher ;

Nelson, Michael ;

Evans, Ronald M. ;

Yates, John ;

Montminy, Marc .

SCIENCE, 2006, 312 (5781) :1763-1766

[62] Ubiquitin E3 ligase SCFβ-TRCP regulates TRIB2 stability in liver cancer cells [J].

Qiao, Yongxia ;

Zhang, Yue ;

Wang, Jiayi .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 441 (03) :555-559

[63] Day of the dead: pseudokinases and pseudophosphatases in physiology and disease [J].

Reiterer, Veronika ;

Eyers, Patrick A. ;

Farhan, Hesso .

TRENDS IN CELL BIOLOGY, 2014, 24 (09) :489-505

[64] Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation [J].

Rishi, Loveena ;

Hannon, Maura ;

Salome, Mara ;

Hasemann, Marie ;

Frank, Anne-Katrine ;

Campos, Joana ;

Timoney, Jennifer ;

O'Connor, Caitriona ;

Cahill, Mary R. ;

Porse, Bo ;

Keeshan, Karen .

BLOOD, 2014, 123 (15) :2389-2400

[65] TRIB1 overexpression in acute myeloid leukemia [J].

Roethlisberger, Benno ;

Heizmann, Marc ;

Bargetzi, Mario J. ;

Huber, Andreas R. .

CANCER GENETICS AND CYTOGENETICS, 2007, 176 (01) :58-60

[66] Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation [J].

Salazar, M. ;

Lorente, M. ;

Garcia-Taboada, E. ;

Perez Gomez, E. ;

Davila, D. ;

Zuniga-Garcia, P. ;

Maria Flores, J. ;

Rodriguez, A. ;

Hegedus, Z. ;

Mosen-Ansorena, D. ;

Aransay, A. M. ;

Hernandez-Tiedra, S. ;

Lopez-Valero, I. ;

Quintanilla, M. ;

Sanchez, C. ;

Iovanna, J. L. ;

Dusetti, N. ;

Guzman, M. ;

Francis, S. E. ;

Carracedo, A. ;

Kiss-Toth, E. ;

Velasco, G. .

CELL DEATH AND DIFFERENTIATION, 2015, 22 (01) :131-144

[67] TRIB2 and the ubiquitin proteasome system in cancer [J].

Salome, Mara ;

Campos, Joana ;

Keeshan, Karen .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2015, 43 :1089-1094

[68] Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia [J].

Sanda, Takaomi ;

Lawton, Lee N. ;

Barrasa, M. Inmaculada ;

Fan, Zi Peng ;

Kohlhammer, Holger ;

Gutierrez, Alejandro ;

Ma, Wenxue ;

Tatarek, Jessica ;

Ahn, Yebin ;

Kelliher, Michelle A. ;

Jamieson, Catriona H. M. ;

Staudt, Louis M. ;

Young, Richard A. ;

Look, A. Thomas .

CANCER CELL, 2012, 22 (02) :209-221

[69] Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site [J].

Scheeff, Eric D. ;

Eswaran, Jeyanthy ;

Bunkoczi, Gabor ;

Knapp, Stefan ;

Manning, Gerard .

STRUCTURE, 2009, 17 (01) :128-138

[70]

Schug J., 2008, CURR PROTOC BIOINFOR, V2

← 1 2 3 4 5 6 7 8 9 10 →