One-pot synthesis of polysubstituted pyridine derivatives using ketene dithioacetals

被引：14
|
作者：
Hagimori, Masayori
Mizuyama, Naoko
Hisadome, Yukari
Nagaoka, Junko
Ueda, Kazuo
Tominaga, Yoshinori
机构：
[1] Fac Environm Studies, Nagasaki 8528521, Japan
[2] Nagasaki Int Univ, Fac Pharmaceut Sci, Sasebo 8593298, Japan
[3] Nagasaki Univ, Fac Engn, Nagasaki 8528521, Japan
来源：
TETRAHEDRON | 2007年 / 63卷 / 11期
关键词：
one-pot synthesis; ketene dithioacetals; GSC (green and sustainable chemistry); heterocyclic compounds;
D O I：
10.1016/j.tet.2006.12.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polysubstituted pyridine derivatives were synthesized by the reaction of ketene dithioacetal, 3,3-bis(methylsulfanyl)methylenemalononitrile 1b. with a variety of active methylene compounds in the presence of either sodium hydroxide or potassium hydroxide as a base in DMSO. This reaction was carried out under economical one-pot reaction conditions (cheap catalyst and solvent) and solved the problem of the odor of methanethiol, commonly derived from reactions of ketene dithioacetals. This is a significant enhancement of GSC (green and sustainable chemistry) in the field of ketene dithioacetal chemistry. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码：2511 / 2518
页数：8
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