Reconstitution of thymic function after stem cell transplantation in humans

被引：38
作者：
Hakim, FT [1 ]
Gress, RE [1 ]
机构：
[1] NCI, Expt Transplantat & Immunol Branch, NIH, Bethesda, MD 20892 USA
来源：
CURRENT OPINION IN HEMATOLOGY | 2002年 / 9卷 / 06期
关键词：
D O I：
10.1097/00062752-200211000-00004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The reconstitution of T-cell populations is a critical component of immune recovery after allogeneic stem cell transplantation. Recent studies have used new techniques to focus on the interplay of thymopoiesis and peripheral expansion that defines T-cell repopulation. Peripheral expansion, driven by host cytokines and antigenic stimulation, dominates early recovery. However, this expansion is often transient and is characterized by limited repertoire diversity. Renewed thymopoiesis has been found to play a critical role in the recovery of repertoire diversity and stable repopulation. The insights gained into the regulation of these processes may provide new therapies to enhance recovery. (C) 2002 Lippincott Williams Wilkins, Inc.
引用
收藏
页码：490 / 496
页数：7
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