The Metabolic Basis of Kidney Cancer

被引：217

作者：

Linehan, W. Marston ^{[1
]}

Schmidt, Laura S. ^{[1
,2
]}

Crooks, Daniel R. ^{[1
]}

Wei, Darmood ^{[1
]}

Srinivasan, Ramaprasad ^{[1
]}

Lang, Martin ^{[1
]}

Ricketts, Christopher J. ^{[1
]}

机构：

[1] NCI, Urol Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] Frederick Lab Canc Res, Basic Sci Program, Frederick, MD USA

来源：

CANCER DISCOVERY | 2019年 / 9卷 / 08期

关键词：

RENAL-CELL CARCINOMA; COMPREHENSIVE MOLECULAR CHARACTERIZATION; TUMOR-SUPPRESSOR PROTEIN; FUMARATE-HYDRATASE; HEREDITARY LEIOMYOMATOSIS; GENE-PRODUCT; REDUCTIVE CARBOXYLATION; GERMLINE MUTATIONS; DEFICIENT CELLS; MTOR ACTIVATION;

D O I：

10.1158/2159-8290.CD-18-1354

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Kidney cancer is not a single disease but represents several distinct types of cancer that have defining histologies and genetic alterations and that follow different clinical courses and have different responses to therapy. Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor's responses to changes in oxygen, iron, nutrient, or energy levels. The identification of these varying genetic bases of kidney cancer has increased our understanding of the biology of this cancer, allowing the development of targeted therapies and the appreciation that it is a cancer driven by metabolic alterations. Significance: Kidney cancer is a complex disease composed of different types of cancer that present with different histologies, clinical courses, genetic changes, and responses to therapy. This review describes the known genetic changes within kidney cancer, how they alter tumor metabolism, and how these metabolic changes can be therapeutically targeted.

引用

页码：1006 / 1021

页数：16

共 136 条

[1] Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling [J].

Adam, Julie ;

Hatipoglu, Emine ;

O'Flaherty, Linda ;

Ternette, Nicola ;

Sahgal, Natasha ;

Lockstone, Helen ;

Baban, Dilair ;

Nye, Emma ;

Stamp, Gordon W. ;

Wolhuter, Kathryn ;

Stevens, Marcus ;

Fischer, Roman ;

Carmeliet, Peter ;

Maxwell, Patrick H. ;

Pugh, Chris W. ;

Frizzell, Norma ;

Soga, Tomoyoshi ;

Kessler, Benedikt M. ;

El-Bahrawy, Mona ;

Ratcliffe, Peter J. ;

Pollard, Patrick J. .

CANCER CELL, 2011, 20 (04) :524-537

[2] S-(2-succinyl)cysteine:: A novel chemical modification of tissue proteins by a Krebs cycle intermediate [J].

Alderson, Nathan L. ;

Wang, Yuping ;

Blatnik, Matthew ;

Frizzell, Norma ;

Walla, Michael D. ;

Lyons, Timothy J. ;

Alt, Nadja ;

Carson, James A. ;

Nagai, Ryji ;

Thorpe, Suzanne R. ;

Baynes, John W. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 450 (01) :1-8

[3] MiT family translocation renal cell carcinoma [J].

Argani, Pedram .

SEMINARS IN DIAGNOSTIC PATHOLOGY, 2015, 32 (02) :103-113

[4] Xp11 Translocation Renal Cell Carcinoma (RCC): Extended Immunohistochemical Profile Emphasizing Novel RCC Markers [J].

Argani, Pedram ;

Hicks, Jessica ;

De Marzo, Angelo M. ;

Albadine, Roula ;

IlleiMd, Peter B. ;

Ladanyi, Marc ;

Reuter, Victor E. ;

Netto, George J. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2010, 34 (09) :1295-1303

[5] Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys [J].

Baba, Masaya ;

Furihata, Mutsuo ;

Hong, Seung-Beom ;

Tessarollo, Lino ;

Haines, Diana C. ;

Southon, Eileen ;

Patel, Vishal ;

Igarashi, Peter ;

Alvord, W. Gregory ;

Leighty, Robert ;

Yao, Masahiro ;

Bernardo, Marcelino ;

Ileva, Lilia ;

Choyke, Peter ;

Warren, Michelle B. ;

Zbar, Berton ;

Linehan, W. Marston ;

Schmidt, Laura S. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (02) :140-154

[6] Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling [J].

Baba, Masaya ;

Hong, Seung-Beom ;

Sharma, Nirmala ;

Warren, Michelle B. ;

Nickerson, Michael L. ;

Iwamatsu, Akihiro ;

Esposito, Dominic ;

Gillette, William K. ;

Hopkins, Ralph F., III ;

Hartley, James L. ;

Furihata, Mutsuo ;

Oishi, Shinya ;

Zhen, Wei ;

Burke, Terrence R., Jr. ;

Linehan, W. Marston ;

Schmidt, Laura S. ;

Zbar, Berton .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (42) :15552-15557

[7] Regulation of mTORC1 by amino acids [J].

Bar-Peled, Liron ;

Sabatini, David M. .

TRENDS IN CELL BIOLOGY, 2014, 24 (07) :400-406

[8] Treatment of renal cell carcinoma: Current status and future directions [J].

Barata, Pedro C. ;

Rini, Brian I. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (06) :507-524

[9] Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status [J].

Bardella, Chiara ;

El-Bahrawy, Mona ;

Frizzell, Norma ;

Adam, Julie ;

Ternette, Nicola ;

Hatipoglu, Emine ;

Howarth, Kimberley ;

O'Flaherty, Linda ;

Roberts, Ian ;

Turner, Gareth ;

Taylor, Jennifer ;

Giaslakiotis, Konstantinos ;

Macaulay, Valentine M. ;

Harris, Adrian L. ;

Chandra, Ashish ;

Lehtonen, Heli J. ;

Launonen, Virpi ;

Aaltonen, Lauri A. ;

Pugh, Christopher W. ;

Mihai, Radu ;

Trudgian, David ;

Kessler, Benedikt ;

Baynes, John W. ;

Ratcliffe, Peter J. ;

Tomlinson, Ian P. ;

Pollard, Patrick J. .

JOURNAL OF PATHOLOGY, 2011, 225 (01) :4-11

[10] An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia [J].

Benita, Yair ;

Kikuchi, Hirotoshi ;

Smith, Andrew D. ;

Zhang, Michael Q. ;

Chung, Daniel C. ;

Xavier, Ramnik J. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (14) :4587-4602

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