Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease

被引：26

作者：

Casademont, J

Miró, O

Rodriguez-Santiago, B

Viedma, P

Blesa, R

Cardellach, F

机构：

[1] Univ Barcelona, Fac Med, IDIBAPS, Hosp Clin,Internal Med Dept,Muscle Res Grp, Barcelona 08036, Catalonia, Spain

[2] Univ Barcelona, ICMSN, IDIBAPS, Hosp Clin,Memory Alzheimer Unit, Barcelona 08036, Catalonia, Spain

[3] IRO, Med & Mol Genet Ctr, Barcelona, Spain

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2003年 / 206卷 / 01期

关键词：

mitochondria; electron transport chain; respiratory chain; rivastigmine; neurodegenerative disorders; dementia;

D O I：

10.1016/S0022-510X(02)00319-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Electron transport chain (ETC) dysfunction has been claimed to contribute to the expression of neurodegenerative disorders. We have investigated the effects of the treatment with rivastigmine, a commonly used cholinesterase inhibitor, on lymphocyte mitochondria of patients with Alzheimer's disease (AD). Increased enzymatic activities of diverse complexes and oxidative capacity of the ETC were found. Enhanced mitochondrial ETC function may contribute to the beneficial effects of rivastigmine on clinical manifestations of AD. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：23 / 26

页数：4