Catalyst-free three-component synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles under solvent-free conditions

被引：5

作者：

Sayahi, Mohammad Hosein ^{[1
]}

Saghanezhad, Seyyed Jafar ^{[2
]}

Mandavi, Mohammad ^{[3
]}

机构：

[1] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran

[2] ACECR Prod Technol Res Inst, POB 61396-84689, Ahvaz, Iran

[3] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, POB 14117-13137, Tehran, Iran

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2019年 / 55卷 / 08期

关键词：

acetophenone oximes; 2-amino-4,6-diarylpyridine-3-carbonitriles; solvent-free synthesis; ONE-POT SYNTHESIS; 2-AMINO-3-CYANOPYRIDINE DERIVATIVES; EFFICIENT; INHIBITORS; DISCOVERY;

D O I：

10.1007/s10593-019-02527-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel efficient one-pot synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles is described. Method involves heating the mixture of an acetophenone oxime, aldehyde, and malononitrile without any catalyst under solvent-free conditions to give the title compounds in good to high yields.

引用

页码：725 / 728

页数：4

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