JNK1, a potential therapeutic target for hepatocellular carcinoma

被引：34

作者：

Chen, Fei ^{[1
]}

Beezhold, Kevin ^{[1
]}

Castranova, Vince ^{[1
]}

机构：

[1] NIOSH, Lab Canc Signaling & Epigenet, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 26505 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1796卷 / 02期

关键词：

JNK1; HCC; Signature genes; ROS; Progenitor cells; Epigenetics; JUN NH2-TERMINAL KINASE; N-TERMINAL-KINASE; VIRUS X-PROTEIN; NECROSIS-FACTOR-ALPHA; C-JUN; GENE-EXPRESSION; OXIDATIVE STRESS; KAPPA-B; TUMOR SUPPRESSION; WNT/BETA-CATENIN;

D O I：

10.1016/j.bbcan.2009.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite tremendous efforts to diagnose and institute new treatment regimens, the prognosis is still extremely poor. Therefore, knowledge of the molecular mechanisms governing the initiation, maintenance and progression of HCC is urgently needed. Recently, several groups have attributed an important role for c-Jun N-terminal kinase 1 (JNK1) in the pathogenesis of human HCC and its close association with the expression of HCC signature genes. In this review the various associations between JNK1 and HCC are discussed with the hope that targeting this pivotal kinase may lead to novel therapeutic approaches for this fatal disease. Published by Elsevier B.V.

引用

页码：242 / 251

页数：10

共 127 条

[11] Redox events in interleukin-1 signaling [J].

Brigelius-Flohé, R ;

Banning, A ;

Kny, M ;

Böl, GF .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2004, 423 (01) :66-73

[12] Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer [J].

Cairo, Stefano ;

Armengol, Carolina ;

De Reynies, Auelien ;

Wei, Yu ;

Thomas, Emilie ;

Renard, Claire-Angelique ;

Goga, Andrei ;

Balakrishnan, Asha ;

Semeraro, Michaela ;

Gresh, Lionel ;

Pontoglio, Marco ;

Strick-Marchand, Helene ;

Levillayer, Florence ;

Nouet, Yann ;

Rickman, David ;

Gauthier, Frederic ;

Branchereau, Sophie ;

Brugieres, Laurence ;

Laithier, Veronique ;

Bouvier, Raymonde ;

Boman, Francoise ;

Basso, Giuseppe ;

Michiels, Jean-Francois ;

Hofman, Paul ;

Arbez-Gindre, Francine ;

Jouan, Helene ;

Chapeau, Marie-Christine Rousselet ;

Berrebi, Dominique ;

Marcellin, Luc ;

Plenat, Francois ;

Zachar, Dominique ;

Joubert, Madeleine ;

Selves, Janick ;

Pasquier, Dominique ;

Bioulac-Sage, Paulette ;

Grotzer, Michael ;

Childs, Margaret ;

Fabre, Monique ;

Buendia, Marie-Annick .

CANCER CELL, 2008, 14 (06) :471-484

[13] Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity [J].

Chamberlain, Stanley D. ;

Redman, Aniko M. ;

Wilson, Joseph W. ;

Deanda, Felix ;

Shotwell, J. Brad ;

Gerding, Roseanne ;

Lei, Huangshu ;

Yang, Bin ;

Stevens, Kirk L. ;

Hassell, Anne M. ;

Shewchuk, Lisa M. ;

Leesnitzer, M. Anthony ;

Smith, Jeffery L. ;

Sabbatini, Peter ;

Atkins, Charity ;

Groy, Arthur ;

Rowand, Jason L. ;

Kumar, Rakesh ;

Mook, Robert A., Jr. ;

Moorthy, Ganesh ;

Patnaik, Samarjit .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (02) :360-364

[14] Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer [J].

Chang, Qingshan ;

Zhang, Yadong ;

Beezhold, Kevin J. ;

Bhatia, Deepak ;

Zhao, Hongwen ;

Chen, Jianguo ;

Castranova, Vince ;

Shi, Xianglin ;

Chen, Fei .

JOURNAL OF HEPATOLOGY, 2009, 50 (02) :323-333

[15] Alternative splicing and bioinformatic analysis of human U12-type introns [J].

Chang, Wen-Cheng ;

Chen, Yung-Chia ;

Lee, Kuo-Ming ;

Tarn, Woan-Yuh .

NUCLEIC ACIDS RESEARCH, 2007, 35 (06) :1833-1841

[16]

Chen F, 2003, CANCER RES, V63, P7689

[17]

CHEN F, 2009, EUROPEAN J GASTROENT, P21

[18] Beyond apoptosis of JNK1 in liver cancer [J].

Chen, Fei ;

Castranova, Vince .

CELL CYCLE, 2009, 8 (08) :1145-1147

[19] Gene expression patterns in human liver cancers [J].

Chen, X ;

Cheung, ST ;

So, S ;

Fan, ST ;

Barry, C ;

Higgins, J ;

Lai, KM ;

Ji, JF ;

Dudoit, S ;

Ng, IOL ;

van de Rijn, M ;

Botstein, D ;

Brown, PO .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (06) :1929-1939

[20] Nonproteolytic Functions of Ubiquitin in Cell Signaling [J].

Chen, Zhijian J. ;

Sun, Lijun J. .

MOLECULAR CELL, 2009, 33 (03) :275-286

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