Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease

被引：25
作者：
Ranchet, M. [1 ,2 ]
Orlosky, J. [1 ]
Morgan, J. [3 ,4 ,5 ]
Qadir, S. [3 ]
Akinwuntan, A. E.
Devos, H. [4 ,5 ]
机构：
[1] Augusta Univ, Dept Phys Therapy, Coll Allied Hlth Sci, Augusta, GA USA
[2] Univ Lyon, F-69000 Lyon, France
[3] French Inst Sci & Technol Transport, Dev & Networks IFSTTAR, LESCOT, F-69500 Bron, France
[4] Osaka Univ, Toyonaka Educ Res Ctr 5F, Cybermedia Ctr, 32 Machikaneyama, Toyonaka, Osaka 5600043, Japan
[5] Augusta Univ, Dept Neurol, Movement & Cognit Disorders Ctr, Kansas City, GA USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2017年 / 327卷
关键词：
Parkinson's disease; Cognitive workload; Prosaccade task; Antisaccade task; Executive function; VISUALLY-GUIDED SACCADES; EYE-MOVEMENT; DEFICITS; MOTOR; ANTISACCADES; IMPAIRMENT; PEOPLE; LOAD;
D O I：
10.1016/j.bbr.2017.03.043
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score >= 26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score < 26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：162 / 166
页数：5
相关论文
共 25 条
[1]   Dissociating cognitive deficits involved in voluntary eye movement dysfunctions in Parkinson's disease patients [J].
Amador, Silvia C. ;
Hood, Ashley J. ;
Schiess, Mya C. ;
Izor, Robert ;
Sereno, Anne B. .
NEUROPSYCHOLOGIA, 2006, 44 (08) :1475-1482
[2]   Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study [J].
Antoniades, Chrystalina A. ;
Demeyere, Nele ;
Kennard, Christopher ;
Humphreys, Glyn W. ;
Hu, Michele T. .
MOVEMENT DISORDERS, 2015, 30 (06) :843-847
[3]   TASK-EVOKED PUPILLARY RESPONSES, PROCESSING LOAD, AND THE STRUCTURE OF PROCESSING RESOURCES [J].
BEATTY, J .
PSYCHOLOGICAL BULLETIN, 1982, 91 (02) :276-292
[4]  
Beatty J., 2000, HDB PSYCHOPHYSIOL
[5]   Automatic orienting of visuospatial attention in Parkinson's disease [J].
Briand, KA ;
Hening, W ;
Poizner, H ;
Sereno, AB .
NEUROPSYCHOLOGIA, 2001, 39 (11) :1240-1249
[6]   Response times for visually guided saccades in persons with Parkinson's disease: A meta-analytic review [J].
Chambers, Jonathan M. ;
Prescott, Tony J. .
NEUROPSYCHOLOGIA, 2010, 48 (04) :887-899
[7]   Deficits in saccadic eye-movement control in Parkinson's disease [J].
Chan, F ;
Armstrong, IT ;
Pari, G ;
Riopelle, RJ ;
Munoz, DP .
NEUROPSYCHOLOGIA, 2005, 43 (05) :784-796
[8]   A randomized trial of deep-brain stimulation for Parkinson's disease [J].
Deuschl, Guenther ;
Schade-Brittinger, Carmen ;
Krack, Paul ;
Volkmann, Jens ;
Schaefer, Helmut ;
Boetzel, Kai ;
Daniels, Christine ;
Deutschlaender, Angela ;
Dillmann, Ulrich ;
Eisner, Wilhelm ;
Gruber, Doreen ;
Hamel, Wolfgang ;
Herzog, Jan ;
Hilker, Ruediger ;
Klebe, Stephan ;
Kloss, Manja ;
Koy, Jan ;
Krause, Martin ;
Kupsch, Andreas ;
Lorenz, Delia ;
Lorenzl, Stefan ;
Mehdorn, H. Maximilian ;
Moringlane, Jean Richard ;
Oertel, Wolfgang ;
Pinsker, Marcus O. ;
Reichmann, Heinz ;
Reuss, Alexander ;
Schneider, Gerd-Helge ;
Schnitzler, Alfons ;
Steude, Ulrich ;
Sturm, Volker ;
Timmermann, Lars ;
Tronnier, Volker ;
Trottenberg, Thomas ;
Wojtecki, Lars ;
Wolf, Elisabeth ;
Poewe, Werner ;
Voges, Juergen .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :896-908
[9]   Driving and Off-Road Impairments Underlying Failure on Road Testing in Parkinson's Disease [J].
Devos, Hannes ;
Vandenberghe, Wim ;
Tant, Mark ;
Akinwuntan, Abiodun E. ;
De Weerdt, Willy ;
Nieuwboer, Alice ;
Uc, Ergun Y. .
MOVEMENT DISORDERS, 2013, 28 (14) :1949-1956
[10]   Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030 [J].
Dorsey, E. R. ;
Constantinescu, R. ;
Thompson, J. P. ;
Biglan, K. M. ;
Holloway, R. G. ;
Kieburtz, K. ;
Marshall, F. J. ;
Ravina, B. M. ;
Schifitto, G. ;
Siderowf, A. ;
Tanner, C. M. .
NEUROLOGY, 2007, 68 (05) :384-386
123