Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model

被引:63
作者
Kratkiewicz, Karl [1 ]
Manwar, Rayyan [1 ]
Rajabi-Estarabadi, Ali [2 ]
Fakhoury, Joseph [3 ]
Meiliute, Jurgita [4 ]
Daveluy, Steven [5 ,6 ]
Mehregan, Darius [3 ]
Avanaki, Kamran [1 ,3 ,5 ,6 ]
机构
[1] Wayne State Univ, Dept Biomed Engn, Detroit, MI 48201 USA
[2] Univ Miami, Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA
[3] Wayne State Univ, Sch Med, Detroit, MI 48201 USA
[4] EKSPLA USA, Bozeman, MT 59715 USA
[5] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA
[6] Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USA
关键词
photoacoustic imaging; cancer imaging; skin imaging; ultrasound; optical coherence tomography; melanoma; swine melanoma model; ELECTRICAL-IMPEDANCE SPECTROSCOPY; PHOTOACOUSTIC COMPUTED-TOMOGRAPHY; HIGH-FREQUENCY ULTRASOUND; BASAL-CELL CARCINOMA; IN-VIVO; CUTANEOUS MELANOMA; CANCER-DETECTION; DIAGNOSIS; MICROSCOPY; DERMOSCOPY;
D O I
10.3390/s19122815
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The marked increase in the incidence of melanoma coupled with the rapid drop in the survival rate after metastasis has promoted the investigation into improved diagnostic methods for melanoma. High-frequency ultrasound (US), optical coherence tomography (OCT), and photoacoustic imaging (PAI) are three potential modalities that can assist a dermatologist by providing extra information beyond dermoscopic features. In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation.
引用
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页数:14
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