A Link between Bone Mineral Density and Serum Adiponectin and Visfatin Levels in Acromegaly

被引:57
作者
Sucunza, Nuria [1 ,2 ,3 ,4 ]
Jose Barahona, M. [2 ,3 ,4 ,5 ]
Resmini, Eugenia [2 ,3 ,4 ]
Fernandez-Real, Jose-Manuel [6 ,7 ]
Ricart, Wifredo [6 ,7 ]
Farrerons, Jordi [8 ]
Rodriguez Espinosa, Jose [9 ]
Marin, Ana-Maria [8 ]
Puig, Teresa [10 ]
Webb, Susan M. [2 ,3 ,4 ]
机构
[1] Hosp Manacor, Dept Endocrinol, Manacor 07500, Mallorca, Spain
[2] Univ Autonoma Barcelona, Hosp St Pau, Dept Endocrinol, Barcelona 08025, Spain
[3] Univ Autonoma Barcelona, Hosp St Pau, Dept Med, Barcelona 08025, Spain
[4] Univ Autonoma Barcelona, Hosp St Pau, Ctr Invest Biomed Enfermedades Raras, Unidad 747, Barcelona 08025, Spain
[5] Hosp Mutua Terrassa, Dept Endocrinol, Barcelona 08221, Spain
[6] Hosp Josep Trueta, Dept Endocrinol, Inst Invest Biomed Girona, Girona 17007, Spain
[7] Hosp Josep Trueta, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Girona 17007, Spain
[8] Univ Autonoma Barcelona, Hosp St Pau, Dept Internal Med, Barcelona 08025, Spain
[9] Univ Autonoma Barcelona, Hosp St Pau, Dept Biochem, Barcelona 08025, Spain
[10] Univ Autonoma Barcelona, Hosp St Pau, Dept Epidemiol, Barcelona 08025, Spain
关键词
ADIPOSE-SPECIFIC PROTEIN; BODY-COMPOSITION; INSULIN-RESISTANCE; DIABETES-MELLITUS; VISCERAL FAT; WOMEN; LEPTIN; MEN; ASSOCIATION; OSTEOCALCIN;
D O I
10.1210/jc.2009-0474
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly, data on adiponectin are contradictory, and there are no data on visfatin. Objectives: The aim of the study was to evaluate adiponectin and visfatin in acromegaly, compared to control subjects, and to analyze their relationship with body composition and bone markers. Methods: Bone markers [osteocalcin, total amino-terminal propeptide of type 1 procollagen (total P1NP), carboxy-terminal telopeptide (beta-Crosslaps)], body composition (by dual-energy x-ray absorptiometry), adiponectin (by ELISA), and visfatin (by immunoanalysis)] were evaluated in 60 acromegalic patients (24 males and 36 females) and in 105 age-and gender-matched healthy controls (33 males and 72 females). Acromegalic patients were classified as controlled, with normal IGF-I and nadir GH no greater than 1 mu g/liter (n = 41), or active (n = 19). Results: Acromegalic patients had lower adiponectin (P < 0.01), more lean body mass (P < 0.01), more total body mass (P < 0.01), higher bone formation markers (osteocalcin and total P1NP, P < 0.05 and P < 0.01, respectively), but less bone resorption markers (beta-Crosslaps, P < 0.001) than controls. No differences in visfatin and BMD were found between patients and controls. Adiponectin correlated negatively with BMD (r = -0.374; P < 0.05) and lean mass (r = -0.301; P < 0.05) and positively with age (r = 0.341; P < 0.001) in acromegaly. Visfatin correlated negatively with BMD (r = -0.359; P < 0.05). BMD was the predictor for adiponectin and visfatin. Conclusions: Acromegalic patients present hypoadiponectinemia and a favorable bone marker profile. Adiponectin and visfatin could be a link between fat mass and bone in acromegaly. (J Clin Endocrinol Metab 94: 3889-3896, 2009)
引用
收藏
页码:3889 / 3896
页数:8
相关论文
共 44 条
[1]   Decreased plasma adiponectin concentration in patients with essential hypertension [J].
Adamczak, M ;
Wiecek, A ;
Funahashi, T ;
Chudek, J ;
Kokot, F ;
Matsuzawa, Y .
AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (01) :72-75
[2]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[3]   BODY-COMPOSITION IN ACROMEGALY - THE EFFECT OF TREATMENT [J].
BENGTSSON, BA ;
BRUMMER, RJ ;
EDEN, S ;
BOSAEUS, I ;
LINDSTEDT, G .
CLINICAL ENDOCRINOLOGY, 1989, 31 (04) :481-490
[4]   Adiponectin and its receptors are expressed in bone-forming cells [J].
Berner, HS ;
Lyngstadaas, SP ;
Spahr, A ;
Monjo, M ;
Thommesen, L ;
Drevon, CA ;
Syversen, U ;
Reseland, JE .
BONE, 2004, 35 (04) :842-849
[5]   Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways [J].
Boguslawski, G ;
Hale, LV ;
Yu, XP ;
Miles, RR ;
Onyia, JE ;
Santerre, RF ;
Chandrasekhar, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :999-1006
[6]  
Bolanowski M, 2006, NEUROENDOCRINOL LETT, V27, P183
[7]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[8]   The role of the novel adipocyte-derived hormone adiponectin in human disease [J].
Díez, JJ ;
Iglesias, P .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (03) :293-300
[9]   RETRACTED: Visfatin: A protein secreted by visceral fat that mimics the effects of insulin (Retracted article, see vol 318, pg 565, 2007) [J].
Fukuhara, A ;
Matsuda, M ;
Nishizawa, M ;
Segawa, K ;
Tanaka, M ;
Kishimoto, K ;
Matsuki, Y ;
Murakami, M ;
Ichisaka, T ;
Murakami, H ;
Watanabe, E ;
Takagi, T ;
Akiyoshi, M ;
Ohtsubo, T ;
Kihara, S ;
Yamashita, S ;
Makishima, M ;
Funahashi, T ;
Yamanaka, S ;
Hiramatsu, R ;
Matsuzawa, Y ;
Shimomura, I .
SCIENCE, 2005, 307 (5708) :426-430
[10]   Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus [J].
Gerdhem, P ;
Isaksson, A ;
Åkesson, K ;
Obrant, KJ .
OSTEOPOROSIS INTERNATIONAL, 2005, 16 (12) :1506-1512