Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines

被引：15

作者：

Godi, Anna ^{[1
]}

Facchetti, Alessandra ^{[1
,2
]}

Bissett, Sara L. ^{[1
]}

Cocuzza, Clementina ^{[2
]}

Miller, Elizabeth ^{[3
]}

Beddows, Simon ^{[1
]}

机构：

[1] Publ Hlth England, Virus Reference Dept, London, England

[2] Univ Milano Bicocca, Dept Surg & Translat Med, Monza, Italy

[3] Publ Hlth England, Natl Vaccine Evaluat Consortium, London, England

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 06期

关键词：

CERVICAL-CANCER; CONFORMATIONAL EPITOPES; SWISS-MODEL; WOMEN; IMMUNOGENICITY; BINDING;

D O I：

10.1128/JVI.02859-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.

引用

页码：3247 / 3252

页数：6

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